{
  "abstract": "Enzyme-assisted valorisation of crude floral oils into high-value fragrance esters is constrained by mass-transfer limitations and limited productivity in conventional batch reactors. Rose geranium oil, a naturally complex and terpene-rich multicomponent feedstock containing geraniol, citronellol and numerous other volatile constituents, was selected to investigate continuous enzymatic transesterification directly from a crude floral oil. Using Pseudomonas fluorescens lipase (PFL), geraniol and citronellol were selectively transesterified within the multicomponent oil, without prior isolation of these constituents. A process-intensified strategy was developed using a coiled flow inverter (CFI) microreactor. Aqueous-rich biphasic slug flow at an aqueous-to-organic ratio of 9:1, providing a specific interfacial area of 2319 m 2 m -3 , increased the apparent volumetric mass-transfer coefficient (kLa) by approximately 5-fold for geraniol and 7-fold for citronellol relative to batch operation. At 60 °C and a residence time of 5 min, the CFI achieved 99 % geraniol and 93 % citronellol conversion at 0.2 M rose geranium oil, while maintaining 91 % and 71 % conversion, respectively, at 1.4 M. Increasing the residence time to 7 min increased citronellol conversion at 1.4 M to 95 %. At 1.4 M, the 2 mL CFI provided calculated productivities of approximately 572 g day -1 for geranyl ester and 422 g day -1 for citronellyl ester, assuming continuous operation for 24 h. These results establish aqueous-rich segmented flow as an effective strategy for intensifying selective enzymatic transesterification within a compositionally complex terpene feedstock. The combination of selective conversion, enhanced interphase mass transfer and high calculated productivity provides a basis for the continuous valorisation of rose geranium oil and other complex floral oils into high-value fragrance esters.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemical and Environmental Engineering",
    "University of Nottingham",
    "Department of Chemistry",
    "School of Chemical Engineering",
    "University of Adelaide"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Alisa S Wikaputri"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shyam Rana"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rhea Satpute"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Derek J Irvine"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Robert A Stockman"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Volker Hessel"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Parimala Shivaprasad",
      "orcid": "0000-0002-5096-4524"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/be0fbrb2z0pbv.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008471/v1",
  "fulltext_url": null,
  "id": "be0fbrb2z0pbv",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008471/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Innovative Microfluidic and Catalytic Techniques Innovation"
    ]
  ],
  "openalex": "W7211967801",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008471/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/be0fbrb2z0pbv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008471",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008471/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "source:chemrxiv",
      "subfield": "general"
    }
  ],
  "title": "Aqueous-rich flow intensification for enzymatic transesterification of rose geranium oil in a coiled flow inverter microreactor",
  "title_text": "Aqueous-rich flow intensification for enzymatic transesterification of rose geranium oil in a coiled flow inverter microreactor",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/be0fbrb2z0pbv",
  "venue": "ChemRxiv",
  "versions": []
}