{
  "abstract": "BACKGROUND: Unmet needs remain for disease-modifying interventions for the treatment of severe persistent food allergies. In mice models, abatacept, a cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) immunoglobulin fusion protein, promotes immune tolerance to food proteins, and suppresses the initial allergen-related induction of specific immunoglobulin E (IgE) when used as an adjuvant to allergen immunotherapy. METHODS: In this Phase 2a placebo-controlled clinical trial, 14 peanut-allergic participants (14-50 years old) with specific IgE > 50 kU/L were randomized 1:1 to adjuvant abatacept vs. placebo to peanut oral immunotherapy (OIT) for 24 weeks, followed by 12 weeks of OIT alone. With the hypothesis that abatacept suppresses the transient OIT-induced increase in specific IgE, the primary outcome was the relative change from baseline of the peanut-specific/total IgE ratio at 24 weeks. Sustained unresponsiveness was assessed as a secondary outcome with repeated oral food challenges (OFCs) following incremental periods of peanut avoidance. RESULTS: No significant difference in the relative change in peanut-specific/total IgE ratio from baseline was observed between groups (placebo group 87.9% vs. abatacept group 48.2%, p-value 0.26). Median minimal reactive doses on repeated OFCs were similar in both groups (3000 mg) after 4 weeks of peanut avoidance. Lower adverse event rates including anaphylaxis were observed in the abatacept group (5.9 vs. 10 per participant, p-value 0.006). CONCLUSION: Compared to placebo, abatacept did not suppress the allergen-related induction of peanut-specific IgE relative to their total at 24 weeks, but improved OIT tolerability in this severely allergic adult population. Independently of abatacept, most participants achieved sustained unresponsiveness with OIT.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Marie‐lee Simard"
    },
    {
      "name": "Camille Braun"
    },
    {
      "name": "Éloise Antony"
    },
    {
      "name": "Émilie Roy"
    },
    {
      "name": "Marie‐ève Gingras"
    },
    {
      "name": "François Graham"
    },
    {
      "name": "Anne Des Roches"
    },
    {
      "name": "Louis Paradis"
    },
    {
      "name": "Kathryn Samaan"
    },
    {
      "name": "Florence Gingras-Lessard"
    },
    {
      "name": "Roxane Labrosse"
    },
    {
      "name": "Thomas Eiwegger"
    },
    {
      "name": "Philippe Bégin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/beg56tq6jrrgt.bib",
  "cited_by": 0,
  "doi": "10.1111/all.70531",
  "fulltext_url": null,
  "id": "beg56tq6jrrgt",
  "issns": [
    "0105-4538",
    "1398-9995"
  ],
  "landing_url": "https://hal.science/hal-05795471v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.imm"
    ],
    [
      "hal",
      "2.sdv.imm.all"
    ],
    [
      "openalex",
      "2723|Food Allergy and Anaphylaxis Research"
    ]
  ],
  "openalex": "W7214943597",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.70531",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/beg56tq6jrrgt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:55Z",
      "native_id": "hal-05795471",
      "source": "hal",
      "url": "https://hal.science/hal-05795471v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy",
  "title_text": "Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:55Z",
  "url": "https://research.draconitic.com/paper/beg56tq6jrrgt",
  "venue": "Allergy",
  "versions": []
}