{
  "abstract": "Plasma biomarkers that reflect distinct stages of Alzheimer’s disease (AD) could enable scalable biological staging. We evaluated phosphorylated tau (p-tau) species across multiple analytical platforms and the endogenously cleaved microtubule-binding region containing residue 243 (eMTBR-tau243) using a dedicated LC-MS/MS platform in a well-characterized cohort with amyloid PET and a subset with tau PET. While T1 biomarkers increased during preclinical stages, eMTBR-tau243 and p-tau205 increased later, consistent with fibrillar tau aggregation. eMTBR-tau243 showed the strongest and stage-dependent associations with regional tau PET and cognition, outperforming T1 biomarkers in predicting cross-sectional and longitudinal cognition. A plasma-based tau staging system integrating p-tau217 and eMTBR-tau243 closely aligned with PET-based tau staging and predicted longitudinal cognitive trajectories. These findings support plasma eMTBR-tau243 as a prototypical T2 biomarker and highlight the potential of plasma-based tau staging for prognosis and therapeutic decision-making in AD.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "name": "Sohyun Yim",
      "orcid": "0000-0002-9357-768X"
    },
    {
      "name": "Eun Hye Lee",
      "orcid": "0000-0002-4206-6214"
    },
    {
      "name": "Jungah Lee",
      "orcid": "0000-0003-4989-9670"
    },
    {
      "name": "Daeun Shin"
    },
    {
      "name": "Heekyoung Kang"
    },
    {
      "name": "Hee Kyung Park"
    },
    {
      "name": "Seonghyeon Kim"
    },
    {
      "name": "Joel B. Braunstein"
    },
    {
      "name": "Philip B. Verghese",
      "orcid": "0000-0003-4793-564X"
    },
    {
      "name": "Tim West",
      "orcid": "0000-0003-3267-8249"
    },
    {
      "name": "Matthew R. Meyer"
    },
    {
      "name": "Theresa A. Day"
    },
    {
      "name": "Henrik Zetterberg",
      "orcid": "0000-0003-3930-4354"
    },
    {
      "name": "Fernando Gonzalez-Ortiz",
      "orcid": "0000-0001-7897-9456"
    },
    {
      "name": "Nicholas J. Ashton",
      "orcid": "0000-0002-3579-8804"
    },
    {
      "name": "Tobias Bittner"
    },
    {
      "name": "Annunziata Di Domenico"
    },
    {
      "name": "Gwendlyn Kollmorgen"
    },
    {
      "name": "Hyemin Jang"
    },
    {
      "name": "Jihwan Yun"
    },
    {
      "name": "Min Young Chun"
    },
    {
      "name": "Duk L. Na",
      "orcid": "0000-0002-0098-7592"
    },
    {
      "name": "Hee Jin Kim"
    },
    {
      "name": "Yuna Gu"
    },
    {
      "name": "Jun Pyo Kim",
      "orcid": "0000-0003-4376-3107"
    },
    {
      "name": "Sang Won Seo",
      "orcid": "0000-0002-8747-0122"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ber9ad7vncjra.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78582-x",
  "fulltext_url": null,
  "id": "ber9ad7vncjra",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78582-x",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7222934409",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78582-x_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-19",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/ber9ad7vncjra.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-78582-x",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78582-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Plasma eMTBR-tau243 and p-tau205 as T2 biomarkers for biological staging and prognosis in Alzheimer’s disease",
  "title_text": "Plasma eMTBR-tau243 and p-tau205 as T2 biomarkers for biological staging and prognosis in Alzheimer’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/ber9ad7vncjra",
  "venue": "Nature Communications",
  "versions": []
}