{
  "abstract": "Synchronous ultrasound parallel beam (SUPERB) technology heats the mid-dermis without relying on hemoglobin as an optical chromophore, but its effect on the cutaneous microvasculature has not been reported. We examined short-term responses of a hypervascular chicken comb model to SUPERB treatment combined with applicator compression. In six adult roosters, two sites on the left comb surface each received a single pulse of 3 to 5 J after compression blanching, and the right surface served as a within-animal control. Full-thickness biopsies were taken immediately after treatment and on days 3 and 7; one rooster died on day 2, leaving five for analysis. Hematoxylin and eosin sections were assessed descriptively by a blinded pathologist, and vascular endothelial growth factor A (VEGF-A) positive area and Masson collagen area were quantified on day 7 at the animal level. Reduced microvascular caliber and fewer intraluminal erythrocytes were recorded at 1 of 10 sites immediately after treatment, 8 of 10 sites on day 3 and 8 of 9 evaluable sites on day 7. On day 7, VEGF-A positive area was lower on the treated side in all five animals (11.5% vs. 20.5%; mean paired difference -9.1 percentage points, 95% confidence interval -13.3 to -4.9; exact Wilcoxon p = 0.0625, the smallest value attainable with five pairs). Collagen area did not change consistently. Tissue temperature and perfusion were not measured, and no sham-compression group was included. These hypothesis-generating findings support controlled studies that separate the effects of compression and ultrasound energy.",
  "abstract_shown": true,
  "affiliations": [
    "Zibo Municipal Hospital"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "T. Zhang"
    },
    {
      "name": "R. Wang"
    },
    {
      "name": "Z. Yang"
    },
    {
      "name": "G. Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bevs8x06t0f18.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.01.763470",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763470v1.full",
  "id": "bevs8x06t0f18",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763470v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "pathology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763470v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bevs8x06t0f18.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:14Z",
      "native_id": "10.64898/2026.11.01.763470",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763470v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:pathology",
      "subfield": "general"
    }
  ],
  "title": "Short-term changes in a chicken comb vascular model mimicking port-wine stain after synchronous ultrasound parallel beam treatment: an exploratory study",
  "title_text": "Short-term changes in a chicken comb vascular model mimicking port-wine stain after synchronous ultrasound parallel beam treatment: an exploratory study",
  "type": "preprint",
  "updated_at": "2026-11-05T00:20:43Z",
  "url": "https://research.draconitic.com/paper/bevs8x06t0f18",
  "venue": "bioRxiv",
  "versions": []
}