{
  "abstract": "Dietary antioxidants offer protection against oxidative bursts caused by high-intensity physical exercise. However, their acute effects on specific lipid oxidation products, especially oxidized phosphatidylcholine (oxPC) and oxysterols, remain underexplored in human plasma. Nineteen female participants underwent a crossover study involving pre-exercise intake of either polyphenol-enriched flaxseed oil (FO) or water (control), followed by standardized high-intensity interval training (HIIT). Plasma collected at four time points (pre- to post-HIIT) was analyzed via targeted LC-MS/MS for oxPCs and oxysterols and untargeted lipidomics using LC-QTOF-MS. FO significantly suppressed the postexercise rise in oxPCs (e.g., SONPC, KOOA-PC, KDdiA-PC) and nonenzymatically formed oxysterols (7-ketocholesterol, 7β-hydroxycholesterol). Orthogonal PLS-DA showed obvious postexercise group separation between FO-consuming subjects versus control. Untargeted lipidomics revealed broader remodeling of the phospholipidome in the FO group. This study provides novel evidence that polyphenol-rich FO acutely mitigates lipid peroxidation, supporting its potential as a nutritional strategy for oxidative stress management.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Josef-Holaubek-Platz 2, Vienna1090, Austria.",
    "Research Center for Food Technology and Processing, National Research and Innovation Agency, Yogyakarta55861, Indonesia.",
    "Vienna Doctoral School in Chemistry (DoSChem), Faculty of Chemistry, University of Vienna, Währinger Str. 42, Vienna1090, Austria.",
    "Department of Nutrition, Faculty of Life Sciences, Section for Nutrition, Exercise and Health, University of Vienna, Vienna1090, Austria.",
    "Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz, Vienna1090, Austria.",
    "Centre for Sport Science and University Sports, Department of Sports Science, Section for Nutrition, Exercise and Health, University of Vienna, Auf der Schmelz 6, Vienna1150, Austria."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Fawzan Sigma Aurum"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia Brem"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Matthias Strauss",
      "orcid": "0000-0003-0078-1612"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Markus Gassner"
    },
    {
      "affs": [
        3,
        5,
        4
      ],
      "name": "Daniel König"
    },
    {
      "affs": [
        0
      ],
      "name": "Marc Pignitter",
      "orcid": "0000-0002-5793-8572"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bfc1psxqfjhjc.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.jafc.6c08737",
  "fulltext_url": "https://europepmc.org/articles/PMC13651599",
  "id": "bfc1psxqfjhjc",
  "issns": [
    "0021-8561",
    "1520-5118"
  ],
  "landing_url": "https://europepmc.org/article/MED/42915783",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Exercise and Physiological Responses"
    ]
  ],
  "openalex": "W7214049790",
  "pdf_url": "https://europepmc.org/articles/PMC13651599?pdf=render",
  "pmcid": "PMC13651599",
  "pmid": "42915783",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bfc1psxqfjhjc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42915783",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42915783"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Exercise and Physiological Responses",
      "subfield": "general"
    }
  ],
  "title": "Oxidomics of Human Plasma Reveals Lower Oxidized Lipids After Acute Intake of Polyphenol-Enriched Flaxseed Oil: A Randomized Crossover Exercise Trial.",
  "title_text": "Oxidomics of Human Plasma Reveals Lower Oxidized Lipids After Acute Intake of Polyphenol-Enriched Flaxseed Oil: A Randomized Crossover Exercise Trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/bfc1psxqfjhjc",
  "venue": "Journal of agricultural and food chemistry",
  "versions": []
}