{
  "abstract": "Background\n\nStem cell therapies have emerged as a promising strategy for repairing structural damage and modulating inflammation in chronic obstructive pulmonary disease (COPD). However, a comprehensive characterization of the global clinical trial landscape remains lacking.Methods\n\nWe retrospectively analyzed clinical trials of stem cell therapy for COPD registered in the Trialtrove database up to October 1, 2025, supplemented by cross-referencing with ClinicalTrials.gov. Key trial characteristics were independently extracted and cross-checked by 2 investigators.Results\n\nA total of 43 eligible trials were identified. Early-phase studies (Phase I-II) accounted for over 80% of all trials. Mesenchymal stromal cell (MSC)-based therapies and mixed cell populations each accounted for 34.9% of registered trials, followed by bronchial basal progenitor cell-based therapies (23.3%). Among 25 completed trials, only 11 publicly disclosed results. Available findings indicated no major short-term safety concerns for the specific cell products evaluated, whereas efficacy outcomes remained heterogeneous. Academic institutions sponsored most trials, while industry-sponsored studies showed a higher proportion of terminated or inactive trials. The United States and China accounted for the largest numbers of registered trials, although Brazil contributed the greatest number of publicly available outcome reports.Conclusions\n\nStem cell therapy for COPD remains in an early exploratory stage, with low result-disclosure rates and limited late-phase evidence. Standardized trial design, improved data transparency, and large-scale randomized controlled trials are urgently needed to advance clinical translation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.",
    "Department of Neurorehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.",
    "The Second Clinical Medical College, Wenzhou Medical University, Wenzhou 325000, China.",
    "Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tingting Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Wei Dai"
    },
    {
      "affs": [
        2
      ],
      "name": "Ziteng Zhu"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuanrong Dai"
    },
    {
      "affs": [
        0
      ],
      "name": "Chan Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiangting Ge",
      "orcid": "0000-0001-9184-7079"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bfd2hz1gp0nkz.bib",
  "cited_by": 0,
  "doi": "10.1093/stcltm/szag087",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726808/?tool=EBI",
  "id": "bfd2hz1gp0nkz",
  "issns": [
    "2157-6564",
    "2157-6580"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13726808",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00770"
    ],
    [
      "heading",
      "AcademicSubjects/SCI00960"
    ],
    [
      "heading",
      "Brief Report"
    ],
    [
      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
    ]
  ],
  "openalex": "W7225077546",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726808/pdf/?tool=EBI",
  "pmcid": "PMC13726808",
  "pmid": "42970715",
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/bfd2hz1gp0nkz.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13726808",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13726808"
    },
    {
      "first_seen": "2026-11-04T15:20:44Z",
      "native_id": "MED:42970715",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42970715"
    },
    {
      "first_seen": "2026-11-05T12:23:04Z",
      "native_id": "PMC13726808",
      "source": "pmc",
      "url": "https://doi.org/10.1093/stcltm/szag087"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Chronic Obstructive Pulmonary Disease (COPD) Research",
      "subfield": "general"
    }
  ],
  "title": "Stem cell therapies for chronic obstructive pulmonary disease: mapping the global clinical trial landscape",
  "title_text": "Stem cell therapies for chronic obstructive pulmonary disease: mapping the global clinical trial landscape",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:39Z",
  "url": "https://research.draconitic.com/paper/bfd2hz1gp0nkz",
  "venue": "Stem cells translational medicine",
  "versions": []
}