{
  "abstract": "This study aimed to quantify the global dementia burden attributable to anxiety disorders among older adults. We searched PubMed, Embase, and MEDLINE through July, 2024 for cohort studies examining anxiety-related dementia risk, and pooled risk ratios (RRs). Prevalence of anxiety disorders and disability-adjusted life-years (DALYs) for dementia were obtained from Global Burden of Disease (GBD) 2021. Attributable age-standardized DALY rates (ASDRs) were estimated for 1995-2021, with trends and cross-country inequalities assessed. Fourteen studies met inclusion. Anxiety disorders were associated with increased dementia risk (RR: 1.14). Globally, attributable ASDRs declined slightly (23.54 to 22.52 per 100,000, 1995-2021). Highest burdens were observed in Europe and high-middle sociodemographic index (SDI) regions in 2021, while the fastest increases occurred in South-East Asian and low-middle SDI regions. Global inequalities persisted over time. Anxiety contributes to dementia burden in older adults, highlighting the need for targeted interventions in countries and regions with high anxiety-attributable dementia burden.",
  "abstract_shown": true,
  "affiliations": [
    "Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health Zhejiang University School of Medicine Hangzhou Zhejiang China.",
    "Center for Global Health Zhejiang University School of Medicine Hangzhou Zhejiang China.",
    "Department of Psychiatry, the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China.",
    "Zhejiang Key Laboratory of Intelligent Preventive Medicine Hangzhou Zhejiang China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiayao Ying"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiali Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shiyi Shan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xinyu Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Longzhu Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Chenyue Xu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zeyu Luo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jing Wu"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Peige Song"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bfths08zjx0wx.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70537",
  "fulltext_url": "https://europepmc.org/articles/PMC13740354",
  "id": "bfths08zjx0wx",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996801",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7225392111",
  "pdf_url": "https://europepmc.org/articles/PMC13740354?pdf=render",
  "pmcid": "PMC13740354",
  "pmid": "42996801",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bfths08zjx0wx.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42996801",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996801"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Global, regional, and national burden of anxiety-related Alzheimer's disease and Alzheimer's-related dementias among older adults from 1995 to 2021: A comparative risk assessment study.",
  "title_text": "Global, regional, and national burden of anxiety-related Alzheimer's disease and Alzheimer's-related dementias among older adults from 1995 to 2021: A comparative risk assessment study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/bfths08zjx0wx",
  "venue": "Alzheimer's & dementia (Amsterdam, Netherlands)",
  "versions": []
}