{
  "abstract": "We report an autocatalytic molecular amplification system based on the double masking of benzoquinones with boronate ester protecting groups (i.e., diboronate ester probes). This design extends a previously described redox cross‐catalytic (RCC) reaction scheme, in which hydrogen peroxide (H2O2 ) and quinones are exponentially co‐generated through coupled catalytic loops. The double protection aims to enhance the chemical stability of the diboronate probes while preserving their ability to undergo autocatalytic deprotection. Through kinetic modeling and experimental validation, we demonstrate that complete deprotection to the corresponding quinones can occur even under substoichiometric H2O2 conditions, thereby sustaining autocatalytic behavior. Comparative studies of symmetric and asymmetric diboronate probes reveal how molecular structure and electronic effects control the kinetics of each deprotection step and so the overall amplification efficiency. Finally, we show that these doubly protected systems enable efficient responses to H2O2 across more than two orders of magnitude in concentration (from µM to sub‐millimolar range) and within minutes, while providing improved probe stability and tunable reactivity. This work offers mechanistic insights and design principles for next‐generation autocatalytic redox amplification systems with enhanced analytical performance.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Pan Hui"
    },
    {
      "name": "Alexandra Pastor"
    },
    {
      "name": "Mathieu Branca"
    },
    {
      "name": "Benoît Limoges"
    },
    {
      "name": "François Mavré"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bftjj4wn9mtte.bib",
  "cited_by": 0,
  "doi": "10.1002/syst.70042",
  "fulltext_url": null,
  "id": "bftjj4wn9mtte",
  "issns": [
    "2570-4206"
  ],
  "landing_url": "https://hal.science/hal-05760559v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1607|Molecular Sensors and Ion Detection"
    ]
  ],
  "openalex": "W7162770196",
  "pdf_url": "https://hal.science/hal-05760559/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-29",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/bftjj4wn9mtte.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "hal-05760559",
      "source": "hal",
      "url": "https://hal.science/hal-05760559v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Molecular Sensors and Ion Detection",
      "subfield": "physical"
    }
  ],
  "title": "Autocatalytic Deprotection of Diboronate‐Protected Quinones via Redox Cross‐Catalysis: Mechanistic Insights Into Double Masking Strategies",
  "title_text": "Autocatalytic Deprotection of Diboronate‐Protected Quinones via Redox Cross‐Catalysis: Mechanistic Insights Into Double Masking Strategies",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/bftjj4wn9mtte",
  "venue": "ChemSystemsChem",
  "versions": []
}