{
  "abstract": "Alzheimer's disease (AD), a multifaceted neurodegenerative disease, stands as the most prevalent form of dementia and one of the leading causes of death in the elderly. An increasing body of evidence underscores the intricate link between AD and metabolic disturbances. Metabolomics research has unveiled dysregulations in various metabolites within the brain and body fluids of individuals with AD, shedding light on the disease's metabolic underpinnings. Furthermore, notable correlations were identified between particular metabolites and AD-associated pathologies, as well as cognitive phenotypes, throughout the course of AD progression. Despite these valuable insights, a holistic understanding of the metabolic basis of AD is still scarce. This review examines recent studies investigating metabolome changes in different types of specimens from AD individuals. We presented a summary of the metabolic signatures of AD and the correlation between metabolites and AD-related traits. We then delineated the various biochemical pathways by which metabolites are involved in AD pathogenesis. We hope that this review will provide a basis for the further development of biomarkers and therapeutic strategies for metabolic disorders in AD.",
  "abstract_shown": true,
  "affiliations": [
    "Program of Bone-Brain Axis Research, Department of Orthopedics, Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.",
    "Neurodegenerative Disorder Research Center, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.",
    "Program of Bone-Brain Axis Research, Department of Orthopedics, Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. yongshen@ustc.edu.cn.",
    "Neurodegenerative Disorder Research Center, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. yongshen@ustc.edu.cn.",
    "Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. yongshen@ustc.edu.cn.",
    "Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, China. yongshen@ustc.edu.cn."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaoli Yang"
    },
    {
      "affs": [
        2,
        3,
        4,
        5
      ],
      "name": "Yong Shen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bfvd13drkz0ec.bib",
  "cited_by": 0,
  "doi": "10.1186/s13024-026-00982-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13729493",
  "id": "bfvd13drkz0ec",
  "issns": [
    "1750-1326"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972409",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7171924387",
  "pdf_url": "https://europepmc.org/articles/PMC13729493?pdf=render",
  "pmcid": "PMC13729493",
  "pmid": "42972409",
  "published": "2026-07-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bfvd13drkz0ec.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42972409",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972409"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Deciphering the metabolome in Alzheimer's disease.",
  "title_text": "Deciphering the metabolome in Alzheimer's disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T03:21:01Z",
  "url": "https://research.draconitic.com/paper/bfvd13drkz0ec",
  "venue": "Molecular neurodegeneration",
  "versions": []
}