{
  "abstract": "Pure metaplastic squamous cell carcinomas (MSCC) of the breast are rare. We report the case of a 57-year-old woman who presented with a breast abscess in whom a papillomatous lesion was identified during incision and drainage. The initial biopsy demonstrated hyperplastic squamous epithelium with koilocytic atypia, raising the possibility of condylomata acuminata. Subsequent wide excision revealed extensive squamous metaplasia with invasive squamous cell carcinoma arising within a cystic papillary lesion consistent with pure MSCC of the breast. Immunohistochemistry revealed positivity for p63 and negativity for p16, estrogen receptor, progesterone receptor, and human epidermal growth receptor 2. The investigations excluded human papillomavirus infections, cutaneous origins, and extramammary primary squamous cell carcinomas. Following early local recurrence, the patient underwent mastectomy and axillary dissection. Adjuvant radiotherapy and chemotherapy were also administered. This case highlights the diagnostic challenges and aggressive behavior of pure MSCC and emphasizes the importance of clinicopathological correlations and multidisciplinary management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, Hospital Teluk Intan, Teluk Intan, Malaysia .",
    "Breast and Endocrine Surgery Unit, Department of Surgery, Hospital Raja Permaisuri Bainun, Ipoh, Malaysia .",
    "Department of Pathology, Hospital Teluk Intan, Teluk Intan, Malaysia .",
    "Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia ."
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jing Wen Loh",
      "orcid": "0000-0002-9356-3819"
    },
    {
      "affs": [
        1
      ],
      "name": "Ai Chen Chan",
      "orcid": "0000-0001-9754-0473"
    },
    {
      "affs": [
        2
      ],
      "name": "Abdul Kadir Rifaei Abd Rashid Khairi",
      "orcid": "0009-0007-0607-3410"
    },
    {
      "affs": [
        3
      ],
      "name": "Najihah Abu Bakar",
      "orcid": "0009-0005-6338-4819"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bfvtd1rjjx2kq.bib",
  "cited_by": 1,
  "doi": "10.4048/jbc.2026.0091",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13745079/",
  "id": "bfvtd1rjjx2kq",
  "issns": [
    "1738-6756",
    "2092-9900"
  ],
  "landing_url": "https://doi.org/10.4048/jbc.2026.0091",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2734|Breast Lesions and Carcinomas"
    ]
  ],
  "openalex": "W7220738550",
  "pdf_url": null,
  "pmcid": "PMC13745079",
  "pmid": "42834606",
  "published": "2026-09-11",
  "publisher": "Korean Breast Cancer Society",
  "ris": "https://research.draconitic.com/paper/bfvtd1rjjx2kq.ris",
  "sources": [
    {
      "first_seen": "2026-11-11T12:22:42Z",
      "native_id": "PMC13745079",
      "source": "pmc",
      "url": "https://doi.org/10.4048/jbc.2026.0091"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Breast Lesions and Carcinomas",
      "subfield": "general"
    }
  ],
  "title": "Primary Breast Pure Metaplastic Squamous Cell Carcinoma: A Breast Abscess With Squamous Metaplasia and Malignant Transformation That Mimics Condylomata Acuminata",
  "title_text": "Primary Breast Pure Metaplastic Squamous Cell Carcinoma: A Breast Abscess With Squamous Metaplasia and Malignant Transformation That Mimics Condylomata Acuminata",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:20:34Z",
  "url": "https://research.draconitic.com/paper/bfvtd1rjjx2kq",
  "venue": "Journal of Breast Cancer",
  "versions": []
}