{
  "abstract": "Objectives\n\nCisplatin (CDDP) is a potent anticancer agent with significant side effects, including ototoxicity. Capsaicin (CAPS), the active compound in chili peppers, has shown protective effects against CDDP-induced toxicities. This study aimed to investigate the role of capsaicin in CDDP-induced ototoxicity via DNA damage and apoptotic cell death pathways in House Ear Institute Organ of Corti 1 (HEI-OC1) cells and to evaluate its effects on neuroblastoma (KELLY) cells under the same conditions.Methods\n\nHEI-OC1 and KELLY neuroblastoma cells were treated with CDDP (100 μM), CAPS (5 μM), and CAPS+CDDP combinations for 24 h. Cell viability was assessed using the WST-1 assay, and apoptosis was evaluated by Annexin V/PI flow cytometry. DNA damage-related gene expressions were analyzed in HEI-OC1 cells using a real-time PCR array. CAPS alone did not alter the viability of HEI-OC1 or KELLY cells. CDDP significantly reduced the viability of both.Results\n\nCAPS + CDDP combination significantly decreased KELLY cell viability, while only slightly affecting HEI-OC1 cells. Both CDDP alone and CAPS + CDDP induced similar levels of apoptosis in HEI-OC1 cells. In KELLY cells, the combination induced greater apoptosis than CDDP alone. CDDP treatment upregulated DNA damage-related genes and downregulated DNA repair genes in HEI-OC1 cells. CAPS + CDDP treatment altered expression profiles, suggesting a role in DNA repair modulation.Conclusion\n\nCapsaicin may serve as a moderate protective agent against cisplatin-induced ototoxicity without compromising cisplatin's cytotoxic effects on neuroblastoma cells. Changes in DNA repair-related gene expression support capsaicin's involvement in modulating the cellular response to cisplatin.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Basic Oncology Dokuz Eylül University Institute of Oncology Izmir Turkey.",
    "Department of Otorhinolaryngology Dokuz Eylül University Faculty of Medicine İzmir Turkey."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yavuz Kerem Altun",
      "orcid": "0009-0001-5632-312X"
    },
    {
      "affs": [
        1
      ],
      "name": "Yüksel Olgun",
      "orcid": "0000-0003-1769-4224"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayça Pamukoğlu Kaynar",
      "orcid": "0009-0003-4307-4878"
    },
    {
      "affs": [
        0
      ],
      "name": "Safiye Aktaş",
      "orcid": "0000-0002-7658-5565"
    },
    {
      "affs": [
        0
      ],
      "name": "Zekiye Altun",
      "orcid": "0000-0002-1558-4534"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bfx0qsky4tvnq.bib",
  "cited_by": 0,
  "doi": "10.1002/lio2.70598",
  "fulltext_url": "https://europepmc.org/articles/PMC13686354",
  "id": "bfx0qsky4tvnq",
  "issns": [
    "2378-8038"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910052",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Chemotherapy-induced organ toxicity mitigation"
    ]
  ],
  "openalex": "W7223134188",
  "pdf_url": "https://europepmc.org/articles/PMC13686354?pdf=render",
  "pmcid": "PMC13686354",
  "pmid": "42910052",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bfx0qsky4tvnq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42910052",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910052"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Chemotherapy-induced organ toxicity mitigation",
      "subfield": "general"
    }
  ],
  "title": "Capsaicin Modulates DNA Damage Related Gene Expressions in Cisplatin-Induced Ototoxicity.",
  "title_text": "Capsaicin Modulates DNA Damage Related Gene Expressions in Cisplatin-Induced Ototoxicity.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/bfx0qsky4tvnq",
  "venue": "Laryngoscope investigative otolaryngology",
  "versions": []
}