{
  "abstract": "Urolithin A (Uro A) is a natural bioactive compound biosynthesized by the gut microbiota after the ingestion of foods that are rich in ellagic acid and ellagitannins, such as strawberries, pomegranate, raspberries and walnuts. Uro A is studied in preclinical and clinical studies for its numerous biological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective and neuroprotective properties, while also possessing a therapeutic potential against metabolic syndrome and mitochondrial-enhancing effects. This narrative review briefly outlines the biosynthesis of Uro A and current evidence on its biological properties and its potential role in mitigating diseases, on the basis of literature searches performed on Google Scholar, Scopus, and PubMed/MEDLINE. In addition, recent clinical trials based on the supplementation with Uro A are summarized herein.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, Italy",
    "Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70126 Bari, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anna Chiara Tenuta"
    },
    {
      "affs": [
        0
      ],
      "name": "Domenico Iacopetta",
      "orcid": "0000-0001-5179-7118"
    },
    {
      "affs": [
        1
      ],
      "name": "Alessia Catalano",
      "orcid": "0000-0002-7420-4706"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Aiello",
      "orcid": "0000-0001-6846-5582"
    },
    {
      "affs": [
        0
      ],
      "name": "Jessica Ceramella",
      "orcid": "0000-0002-1386-3601"
    },
    {
      "affs": [
        0
      ],
      "name": "Eva Scarcelli",
      "orcid": "0009-0004-5303-4148"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Luisa Conforti",
      "orcid": "0000-0001-8364-1783"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniela Bonofiglio",
      "orcid": "0000-0002-4142-0496"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Stefania Sinicropi",
      "orcid": "0000-0003-2435-8931"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bgbt6vd6hyvn0.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31213982",
  "fulltext_url": null,
  "id": "bgbt6vd6hyvn0",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/21/3982",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/bgbt6vd6hyvn0.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T00:20:53Z",
      "native_id": "10.3390/molecules31213982",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/21/3982"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:1420-3049",
      "subfield": "general"
    }
  ],
  "title": "Urolithin A: Biosynthesis at a Glance and Biological Properties Supported by Recent Preclinical and Clinical Evidence",
  "title_text": "Urolithin A: Biosynthesis at a Glance and Biological Properties Supported by Recent Preclinical and Clinical Evidence",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:09Z",
  "url": "https://research.draconitic.com/paper/bgbt6vd6hyvn0",
  "venue": "Molecules",
  "versions": []
}