{
  "abstract": "Here, we present a comparative study of direct and photocatalyst-mediated photoactivation of reporter-functionalised Pt(IV) prodrugs, Carbo-4NP and CarboNap. Direct blue-light irradiation and green-light activation using the photocatalyst Rose Bengal both achieved rapid and complete Pt(IV) reduction in solution, monitored by UV-Vis and fluorescence spectroscopy. Translation to live cells revealed a marked divergence between the two approaches. Direct blue light (415 nm) photoactivation produced >300-fold enhancement in fluorescence intensities upon probe activation and >10-fold in cytotoxicity. Photocatalytic activation was considerably less effective in cells despite its excellent solution-phase performance. These findings identify direct photoactivation as the superior strategy for intracellular activation of Pt(IV) prodrugs and support the further development of direct light-activated platinum therapeutics.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.",
    "Centre for Host-Microbiome Interactions, King's College London, SE1 1UL, London, UK.",
    "Institute of Biomedical Engineering, Department of Engineering Sciences, Old Road Campus Research Building, University of Oxford, Headington, Oxford, UK.",
    "Graduate School of Health Sciences, Cellular and Molecular Medicine Program, Koç University, Istanbul, 34450, Turkey.",
    "Department of Chemistry, Koç University, Istanbul 34450, Türkiye.",
    "Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK. j.callan@ulster.ac.uk."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kinjal Mileche"
    },
    {
      "affs": [
        0
      ],
      "name": "Susana M Meza Huaman"
    },
    {
      "affs": [
        0
      ],
      "name": "Ke Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jake A Vickery",
      "orcid": "0009-0000-8589-6472"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hannah Coxhead"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexander N Smith-Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Patricia Juhl Allworthy"
    },
    {
      "affs": [
        2
      ],
      "name": "Jovana Katrinka-Mavrak"
    },
    {
      "affs": [
        3
      ],
      "name": "Aminesena Baser",
      "orcid": "0000-0001-8018-357X"
    },
    {
      "affs": [
        4
      ],
      "name": "Safacan Kolemen",
      "orcid": "0000-0003-4162-5587"
    },
    {
      "affs": [
        0
      ],
      "name": "Manuel M Müller",
      "orcid": "0000-0001-6701-0893"
    },
    {
      "affs": [
        1
      ],
      "name": "Mahvash Tavassoli"
    },
    {
      "affs": [
        0
      ],
      "name": "Ismael Diez-Perez",
      "orcid": "0000-0003-0513-8888"
    },
    {
      "affs": [
        2
      ],
      "name": "Eleanor Stride",
      "orcid": "0000-0003-3371-5929"
    },
    {
      "affs": [
        5
      ],
      "name": "John F Callan",
      "orcid": "0000-0002-9286-1312"
    },
    {
      "affs": [
        0
      ],
      "name": "Adam C Sedgwick",
      "orcid": "0000-0002-3132-2913"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bgfezypk8v68c.bib",
  "cited_by": 0,
  "doi": "10.1039/d6dt01745b",
  "fulltext_url": "https://europepmc.org/articles/PMC13678618",
  "id": "bgfezypk8v68c",
  "issns": [
    "1477-9226",
    "1477-9234"
  ],
  "landing_url": "https://europepmc.org/article/MED/42895112",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Metal complexes synthesis and properties"
    ]
  ],
  "openalex": "W7221538924",
  "pdf_url": "https://pubs.rsc.org/dt/article-pdf/doi/10.1039/D6DT01745B/14869078/d6dt01745b.pdf",
  "pmcid": "PMC13678618",
  "pmid": "42895112",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bgfezypk8v68c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42895112",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42895112"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Metal complexes synthesis and properties",
      "subfield": "oncology"
    }
  ],
  "title": "Comparative study of the direct and photocatalytic light activation of platinum(IV) prodrugs.",
  "title_text": "Comparative study of the direct and photocatalytic light activation of platinum(IV) prodrugs.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/bgfezypk8v68c",
  "venue": "Dalton transactions (Cambridge, England : 2003)",
  "versions": []
}