{
  "abstract": "Mild cognitive impairment (MCI) may involve impaired dynamic regulation of brain states that is not captured by conventional resting-state electroencephalography (EEG). We quantified occipital alpha (8-12 Hz) transitions during three repeated eye-opening/eye-closure cycles in 60 healthy controls (HC) and 77 participants with MCI. Eye-state events were refined from frontal ocular artifacts. Transition magnitude was measured by the log-transformed post-/pre-event energy ratio, and transition success by the expected direction of alpha change. For canonical transitions meeting prespecified fit-quality criteria, mono-exponential fitting yielded transition onset (tonset) and the post-onset time constant ({tau}). MCI showed weaker alpha suppression during eye opening, weaker alpha enhancement during eye closure, and lower odds of transition success. No significant group difference in {tau} was detected within the canonical quality-controlled subset. In contrast, tonset showed significant Group x Trial interactions in both conditions: HC developed later onset during eye opening and earlier onset during eye closure across repetitions, whereas MCI showed no comparable change. These findings suggest reduced alpha state-transition capacity and altered repetition-dependent temporal organization in MCI.",
  "abstract_shown": true,
  "affiliations": [
    "Affiliated Hospital of Jiangsu University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "X. Wang"
    },
    {
      "name": "Y. Zhu"
    },
    {
      "name": "J. Zhang"
    },
    {
      "name": "z. zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "M. Yu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bgk08nyvhmm8s.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.10.26365211",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.10.26365211v1.full",
  "id": "bgk08nyvhmm8s",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.10.26365211v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7221549456",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.10.26365211v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bgk08nyvhmm8s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:43Z",
      "native_id": "10.64898/2026.10.10.26365211",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.10.26365211v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Attenuated alpha state transitions and disrupted repetition-dependent temporal adaptation in mild cognitive impairment",
  "title_text": "Attenuated alpha state transitions and disrupted repetition-dependent temporal adaptation in mild cognitive impairment",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:43Z",
  "url": "https://research.draconitic.com/paper/bgk08nyvhmm8s",
  "venue": "medRxiv",
  "versions": []
}