{
  "abstract": "Background\n\nAntiviral therapy for cats with feline infectious peritonitis (FIP) has traditionally been administered for 84 days, although the optimal duration of molnupiravir treatment remains unknown.Hypothesis/objectives\n\nTo evaluate the efficacy of a 42-day course of molnupiravir, orally (PO), for naturally occurring FIP in cats.Animals\n\nNineteen client-owned cats with newly diagnosed FIP.Methods\n\nProspective pilot study. Cats received molnupiravir, PO, q12h for 42 days at a median dosage of 11.5 mg/kg (IQR, 10.2-12.5 mg/kg). Cats with ocular or neurological involvement were excluded. Clinical assessments were performed during treatment and for 6 months after treatment cessation.Results\n\nNineteen cats were enrolled. Two cats failed to complete treatment because of death or persistent clinical signs. Fourteen of 19 cats (74%; 95% CI, 49-91) achieved sustained remission on an intention-to-treat basis. Each non-completer failed on day 5 or 10, respectively, within a window common to 42- and 84-day protocols, and therefore do not inform the question of treatment duration; among the 17 cats reaching day 42, 14 (82%; 95% CI, 57-96) remained in remission for at least 6 months. Three cats relapsed after treatment cessation; all responded to retreatment with molnupiravir at the same dosage extended to 84 days.Conclusions and clinical importance\n\nThis prospective study suggests that a shortened course of molnupiravir is feasible in selected cats with non-ocular, non-neurological FIP.Abstract (japanese)\n\n: (FIP) にするウイルスは 84 されてきたが、モルヌピラビルのなはらかではない。 : FIP のにするモルヌピラビル 42 のをすること。 : たに FIP とされた19。 : きパイロット。モルヌピラビルを 12 ごとに 42 した。のは 11.5 mg/kg (、 10.2-12.5 mg/kg) であった。またはをするはした。および 6 か、をった。 : 19 をした。 2 はまたはのによりをできなかった。 Intention-to-treat では 19 14 (74 %； 95% 、 49-91) がをした。の 2 はそれぞれ5および10にとなり、いずれも 42 および 84 のプロトコルにするであったため、のにはしなかった。 42 までをした 17 のうち 14 (82% ； 95% 、 57-96) はなくとも 6 かをした。 3 はにしたが、がのモルヌピラビルによる 84 のにした。 および: きパイロットのから、およびをわない FIP のでは、モルヌピラビルのがであるがされた。.",
  "abstract_shown": true,
  "affiliations": [
    "Veterinary Specialists Emergency Center, Saitama 333-0823, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kenta Hishinuma",
      "orcid": "0009-0006-9913-4413"
    },
    {
      "affs": [
        0
      ],
      "name": "Akiko Inoue",
      "orcid": "0009-0008-7870-109X"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenjiro Fukushima",
      "orcid": "0000-0003-4271-8267"
    },
    {
      "affs": [
        0
      ],
      "name": "Masahiko Sato",
      "orcid": "0000-0002-5611-4483"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bgpytxxw16gjq.bib",
  "cited_by": 0,
  "doi": "10.1093/jvimsj/aalag268",
  "fulltext_url": "https://europepmc.org/articles/PMC13714784",
  "id": "bgpytxxw16gjq",
  "issns": [
    "0891-6640",
    "1939-1676"
  ],
  "landing_url": "https://europepmc.org/article/MED/42949438",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1103|Animal Virus Infections Studies"
    ]
  ],
  "openalex": "W7224089085",
  "pdf_url": "https://europepmc.org/articles/PMC13714784?pdf=render",
  "pmcid": "PMC13714784",
  "pmid": "42949438",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bgpytxxw16gjq.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:35Z",
      "native_id": "MED:42949438",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42949438"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1103|Animal Virus Infections Studies",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Outcomes of a 42-day course of molnupiravir in cats with feline infectious peritonitis: a prospective descriptive study.",
  "title_text": "Outcomes of a 42-day course of molnupiravir in cats with feline infectious peritonitis: a prospective descriptive study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:20:35Z",
  "url": "https://research.draconitic.com/paper/bgpytxxw16gjq",
  "venue": "Journal of veterinary internal medicine",
  "versions": []
}