{
  "abstract": "Temporal lobe epilepsy (TLE) is frequently associated with severe cognitive impairment and psychiatric comorbidities that are highly disabling and not targeted by anti-seizure medications, highlighting the need for therapies that target epileptogenesis rather than merely suppress seizures. Despite strong evidence implicating neuroinflammation in this process, anti-inflammatory approaches have not yielded such therapies yet. Infiltrating peripheral monocytes are widely viewed as detrimental amplifiers of post-status epilepticus (SE) inflammation, although emerging data suggest context-dependent protective roles. The cannabinoid receptor type 2 (CB2), highly expressed in myeloid cells, represents a potential immunomodulatory target linking leukocyte recruitment and inflammatory polarization. Using a juvenile rat model of TLE, we characterized hippocampal neuroinflammation and CB2 expression during epileptogenesis and evaluated the effects of transient CB2 activation with the selective agonist GP1a. SE induced a rapid but transient inflammatory response and robust recruitment of peripheral monocytes that persisted as anti-inflammatory monocyte-derived macrophages. CB2 activation did not suppress early cytokine induction but selectively enhanced recruitment of anti-inflammatory monocytes and modestly increased anti-inflammatory signaling. Importantly, transient CB2 stimulation preserved synaptic plasticity, improved cognitive performance, reduced anxiety-like behavior, and delayed seizure onset. These findings identify CB2-dependent modulation of peripheral myeloid cells as a potential disease-modifying axis in TLE.",
  "abstract_shown": true,
  "affiliations": [
    "Lyon 1 Universite, CNRS UMR5292, Inserm U1028, Centre de Recherche en Neurosciences de Lyon, F-69500 Bron, France"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "W. Grabon"
    },
    {
      "name": "N. Gasmi"
    },
    {
      "name": "A. Ruiz"
    },
    {
      "name": "A. Lang"
    },
    {
      "name": "B. Georges"
    },
    {
      "name": "O. Hurtado"
    },
    {
      "name": "V. Blot"
    },
    {
      "name": "J. Bodennec"
    },
    {
      "name": "S. Rheims"
    },
    {
      "name": "A. Belmeguenai"
    },
    {
      "affs": [
        0
      ],
      "name": "L. Bezin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bgrdgn8jy8p6m.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.30.748087",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748087v1.full",
  "id": "bgrdgn8jy8p6m",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748087v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2738|Epilepsy research and treatment"
    ]
  ],
  "openalex": "W7207658329",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748087v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bgrdgn8jy8p6m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:12Z",
      "native_id": "10.64898/2026.08.30.748087",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748087v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "CB2 activation during epileptogenesis recruits immunomodulatory monocytes and mitigates cognitive, affective and seizure outcomes",
  "title_text": "CB2 activation during epileptogenesis recruits immunomodulatory monocytes and mitigates cognitive, affective and seizure outcomes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:12Z",
  "url": "https://research.draconitic.com/paper/bgrdgn8jy8p6m",
  "venue": "bioRxiv",
  "versions": []
}