{
  "abstract": "Biomanufacturing offers a sustainable alternative to petrochemical manufacturing by harnessing engineered microorganisms to convert renewable feedstocks into diverse value-added products. Systems metabolic engineering has driven its advancement, enabling rational design of microbial strains with enhanced performance and robustness. Despite these achievements, large-scale commercialisation remains limited, highlighting the persistent gap between laboratory success and industrial deployment. We examine the challenges and opportunities in advancing biomanufacturing towards industrial implementation through two cases, succinic acid and polyhydroxyalkanoates, that exemplify products nearing, yet not fully reaching, commercial maturity. Finally, we discuss how integrating artificial intelligence with systems metabolic engineering can accelerate sustainable biomanufacturing. Biomanufacturing holds promise as an alternative to the petrochemical industry, with benefits including increased sustainability as well as improved supply chain resilience, a factor of particular importance in times of geopolitical instability. Here the authors explore both the challenges and opportunities in progressing biomanufacturing from laboratory successes towards industrial-scale deployment.",
  "abstract_shown": true,
  "affiliations": [
    "Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea",
    "Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon, Republic of Korea",
    "BioProcess Engineering Research Center, KAIST, Daejeon, Republic of Korea. leesy@kaist.ac.kr",
    "Center for Synthetic Biology, KAIST, Daejeon, Republic of Korea. leesy@kaist.ac.kr",
    "Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea. leesy@kaist.ac.kr",
    "KAIST Institute for the BioCentury, KAIST, Daejeon, Republic of Korea. leesy@kaist.ac.kr",
    "Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. leesy@kaist.ac.kr",
    "Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon, Republic of Korea. leesy@kaist.ac.kr"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ji Yeon Kim",
      "orcid": "0000-0001-8040-0968"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hye Eun Yu",
      "orcid": "0000-0002-2493-1833"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Min Ho Kim",
      "orcid": "0000-0003-4909-2308"
    },
    {
      "affs": [
        2,
        3,
        4,
        5,
        6,
        7
      ],
      "name": "Sang Yup Lee",
      "orcid": "0000-0003-0599-3091"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bgwr8t67zk0z7.bib",
  "cited_by": 9,
  "doi": "10.1038/s41467-026-73835-1",
  "fulltext_url": null,
  "id": "bgwr8t67zk0z7",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-73835-1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Microbial Metabolic Engineering and Bioproduction"
    ]
  ],
  "openalex": "W7162851884",
  "pdf_url": "https://www.nature.com/articles/s41467-026-73835-1.pdf",
  "pmcid": "PMC13222353",
  "pmid": "42218126",
  "published": "2026-05-30",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/bgwr8t67zk0z7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:48Z",
      "native_id": "W7162851884",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41467-026-73835-1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Microbial Metabolic Engineering and Bioproduction",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Beyond petrochemicals: challenges and opportunities in industrial-scale biomanufacturing",
  "title_text": "Beyond petrochemicals: challenges and opportunities in industrial-scale biomanufacturing",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:43Z",
  "url": "https://research.draconitic.com/paper/bgwr8t67zk0z7",
  "venue": "Nature Communications",
  "versions": []
}