{
  "abstract": "An efficient preparation of highly enantioenriched cyclic compounds from readily available synthons via stereocontrolled organocatalytic processes remains a significant challenge in modern synthetic chemistry. Herein, we report a highly stereoselective N -heterocyclic carbene (NHC)-catalyzed [3+3] annulation of anilines using α-bromocinnamic aldehydes as convenient acyl-azolium precursors. This protocol offers a straightforward route to valuable chiral lactams in high yields (up to 98%) and excellent enantioselectivities (up to 97:3 er ), featuring broad functional group tolerance. Moreover, the reaction is easily scalable and enables versatile downstream derivatizations, further demonstrating the synthetic utility of the developed methodology.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 2030/8, Prague, Czech Republic, 128 00",
    "Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030/8, Prague, Czech Republic, 128 00"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Daniel Čermák"
    },
    {
      "affs": [
        0
      ],
      "name": "Vojtěch Dočekal",
      "orcid": "0000-0003-3957-7977"
    },
    {
      "affs": [
        1
      ],
      "name": "Ivana Císařová"
    },
    {
      "affs": [
        0
      ],
      "name": "Jan Veselý"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bh17dq1qdygst.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010507/v1",
  "fulltext_url": null,
  "id": "bh17dq1qdygst",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010507/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|N-Heterocyclic Carbenes in Organic and Inorganic Chemistry"
    ]
  ],
  "openalex": "W7221939249",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010507/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/bh17dq1qdygst.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010507",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010507/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|N-Heterocyclic Carbenes in Organic and Inorganic Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Enantioselective [3+3] Formal Annulation of Anilines via Carbene Catalysis",
  "title_text": "Enantioselective [3+3] Formal Annulation of Anilines via Carbene Catalysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/bh17dq1qdygst",
  "venue": "ChemRxiv",
  "versions": []
}