{
  "abstract": "Background: Acute ischemic stroke (AIS) is a significant complication of cancer and may reveal occult malignancy. Whether cancer-related AIS (CAS) provides specific biological features remains unclear. Objectives: This case-control study aimed to characterize thrombi and plasmas from patients with CAS. Methods: Nine consecutive patients with CAS, including 3 nonbacterial thrombotic endocarditis (NBTE), and age-and sex-matched AIS controls with cardioembolism (CE, n = 16) or large artery atherosclerosis (LAA, n = 16) were included from the compoCLOT study. Thrombi retrieved after endovascular thrombectomy underwent ex vivo thrombolysis using recombinant tissue-type plasminogen activator and were analyzed for composition. Plasma biomarkers were also assessed. Results: CAS thrombi were resistant to tissue-type plasminogen activator lysis compared with LAA thrombi (median thrombus weight conservation, 92% vs 9%; P = .0002) and, to a lesser extent, compared with CE thrombi (92% vs 43%; P = .06). Thrombolysis resistance correlated negatively with red blood cell content (P < .0001) but positively with platelet factor-4 (P = .0014), von Willebrand factor (P = .0002) and DNA content (P < .0001). A subgroup of macroscopically white thrombi (n = 6), characterized by low red blood cell and high von Willebrand factor content, was identified in CAS, encompassing all 3 NBTE cases. Plasma D-dimer, fibrin monomers, extracellular vesicle-associated tissue factor and myeloperoxidase were significantly higher in patients with CAS than in the combined LAA and CE control groups (31,290 vs 1900 μg/L; 143 vs 9 μg/mL; 143 vs 9 fM; and 51 vs 25 ng/mL, respectively). Conclusions: CAS thrombi exhibit distinct properties, with white thrombi as a hallmark of undiagnosed NBTE. Furthermore, plasma biomarkers such as D-dimer, fibrin monomers, extracellular vesicle-associated tissue factor and myeloperoxidase could help in cancer screening in AIS of unknown etiology.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Capucine Habay"
    },
    {
      "name": "Benoît Ho-Tin-Noé"
    },
    {
      "name": "Mialitiana Solo Nomenjanahary"
    },
    {
      "name": "Véronique Ollivier"
    },
    {
      "name": "Ilham Arab"
    },
    {
      "name": "Lina-Rose Kabbaj"
    },
    {
      "name": "Mikaël Mazighi"
    },
    {
      "name": "Nadine Ajzenberg"
    },
    {
      "name": "Jean-Philippe Desilles"
    },
    {
      "name": "Dorothée Faille"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bh1c5v6j6smn8.bib",
  "cited_by": 0,
  "doi": "10.1016/j.rpth.2026.106787",
  "fulltext_url": null,
  "id": "bh1c5v6j6smn8",
  "issns": [
    "2475-0379",
    "2475-0379"
  ],
  "landing_url": "https://hal.science/hal-05780469v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7164416741",
  "pdf_url": "https://hal.science/hal-05780469/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-11",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/bh1c5v6j6smn8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:48Z",
      "native_id": "hal-05780469",
      "source": "hal",
      "url": "https://hal.science/hal-05780469v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Cancer-associated stroke: a comparative analysis of thrombus composition, resistance to lysis, and plasma biomarkers",
  "title_text": "Cancer-associated stroke: a comparative analysis of thrombus composition, resistance to lysis, and plasma biomarkers",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:48Z",
  "url": "https://research.draconitic.com/paper/bh1c5v6j6smn8",
  "venue": "Research and Practice in Thrombosis and Haemostasis",
  "versions": []
}