{
  "abstract": "Background: Chikungunya virus (CHIKV), primarily transmitted by Aedes mosquitoes, has increasingly caused autochthonous outbreaks in temperate regions, including Italy. In 2025, a local CHIKV outbreak occurred in Verona province, Veneto Region. We report the findings of integrated epidemiological, virological and entomological investigations.\n\nMethods: In 2025, a dedicated surveillance protocol was implemented to assess local transmission of arboviral infections in Verona province, enabling early detection of a local CHIKV circulation. Following notification of the index case, investigations were conducted in accordance with the national and regional arbovirus surveillance plans, including comprehensive epidemiological, virological and entomological analyses.\n\nResults: The index case was identified on 6 August 2025, with retrospective detection of the first case with symptom onset on 31 July; the primary case was not identified. As of 15 October, 69 cases were reported (62 confirmed, 7 probable), with a mean age of 55 years; 91.3% had identifiable epidemiological links, mainly clustered in two municipalities of the Verona province. Most cases (76.8%) occurred between mid-August and mid-September. The outbreak lasted approximately 15 weeks, from the end of July to the mid of October. CHIKV-RNA was detectable in whole blood and, less frequently, urine only within the first 5 days after symptom onset, with higher viral loads in blood. CHIKV-specific IgM antibodies were detectable from Days 4–5 and IgG from Days 7–10. A total of 225 Aedes albopictus specimens were collected, all testing negative for CHIKV. Phylogenetic analysis revealed a highly homogeneous, monophyletic cluster within the East-Central-South African genotype, closely related to strains from the 2024–2025 Réunion outbreak.\n\nConclusions: This outbreak underscores the value of dedicated surveillance protocols for early detection of febrile/suspected arboviral cases, while also highlighting key vulnerabilities, namely, an undetected primary case and negative entomological findings, pointing to the need for lower testing thresholds and earlier, risk-based vector sampling.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 33,
  "authors": [
    {
      "name": "Concetta Castilletti",
      "orcid": "0000-0001-9819-236X"
    },
    {
      "name": "Leonardo Ancillotti"
    },
    {
      "name": "Antonio Mori"
    },
    {
      "name": "Silvia Accordini"
    },
    {
      "name": "Michela Deiana"
    },
    {
      "name": "Samuele Cheri"
    },
    {
      "name": "Natasha Gianesini"
    },
    {
      "name": "Lorena Maria Chesini"
    },
    {
      "name": "Simone Malagò"
    },
    {
      "name": "Andrea Matucci"
    },
    {
      "name": "Federico Cubi"
    },
    {
      "name": "Chiara Zanchi"
    },
    {
      "name": "Paolo Cattaneo"
    },
    {
      "name": "Ralph Huits",
      "orcid": "0000-0001-8803-9468"
    },
    {
      "name": "Luisa Barzon",
      "orcid": "0000-0003-0720-8456"
    },
    {
      "name": "Monia Pacenti"
    },
    {
      "name": "Davide Gentili"
    },
    {
      "name": "Michele Tonon"
    },
    {
      "name": "Chiara Postiglione"
    },
    {
      "name": "Francesco Marchiori"
    },
    {
      "name": "Salvatore Falcone"
    },
    {
      "name": "Tamara Zerman"
    },
    {
      "name": "Federica Gobbo"
    },
    {
      "name": "Christina Merakou"
    },
    {
      "name": "Martina Del Manso"
    },
    {
      "name": "Fabrizio Montarsi"
    },
    {
      "name": "Giulietta Venturi"
    },
    {
      "name": "Patrizio Pezzotti"
    },
    {
      "name": "Dora Buonfrate",
      "orcid": "0000-0003-0108-6822"
    },
    {
      "name": "Giovanna Varischi"
    },
    {
      "name": "Anna Teresa Palamara"
    },
    {
      "name": "Francesca Russo"
    },
    {
      "name": "Federico Giovanni Gobbi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bh4xphecez6j6.bib",
  "cited_by": 0,
  "doi": "10.1093/jtm/taag079",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725053/",
  "id": "bh4xphecez6j6",
  "issns": [
    "1195-1982",
    "1708-8305"
  ],
  "landing_url": "https://doi.org/10.1093/jtm/taag079",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00295"
    ],
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7204637802",
  "pdf_url": "https://academic.oup.com/jtm/advance-article-pdf/doi/10.1093/jtm/taag079/70868056/taag079.pdf",
  "pmcid": "PMC13725053",
  "pmid": "42667651",
  "published": "2026-08-29",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/bh4xphecez6j6.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:31Z",
      "native_id": "PMC13725053",
      "source": "pmc",
      "url": "https://doi.org/10.1093/jtm/taag079"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Mosquito-borne diseases and control",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Autochthonous chikungunya virus outbreak in Verona province, Italy, 2025",
  "title_text": "Autochthonous chikungunya virus outbreak in Verona province, Italy, 2025",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:24Z",
  "url": "https://research.draconitic.com/paper/bh4xphecez6j6",
  "venue": "Journal of Travel Medicine",
  "versions": []
}