{
  "abstract": "ObjectiveTo investigate the dynamic progression and key turning points of quality-of-life (QoL) impairment in patients with capecitabine-induced hand-foot syndrome (HFS) and identify the optimal timing for rehabilitation intervention.MethodsThis secondary analysis included 234 breast cancer patients receiving capecitabine from a multicenter, double-blind randomized controlled trial. HFS-related QoL (HF-QoL), EORTC QLQ-C30, and QLQ-BR23 were assessed longitudinally. Generalized estimating equations examined HFS grade-by-time interactions, and clinically significant deterioration was defined using the minimum clinically important difference (MCID ≥10 points).ResultsSignificant HFS grade-by-time interactions were observed for HF-QoL (β=1.215, 95% CI = [0.689, 1.741], P < 0.001), QLQ-C30 (β=1.464, 95% CI = [0.820, 2.109], P < 0.001), and QLQ-BR23 (β=0.451, 95% CI = [0.148,0.753], P = 0.004), indicating accelerated QoL deterioration with increasing HFS severity. The proportion of patients with clinically significant HF-QoL deterioration increased sharply from Grade 1 to Grade 2 (18.9% vs. 41.9%; OR = 3.053, P = 0.010).ConclusionHFS severity and QoL deterioration show divergent trajectories; Grade 2 may represent a critical threshold at which QoL impairment crosses the threshold of clinical significance; progression from HFS Grade 1 to Grade 2 may be a potential time point for validation in future prospective rehabilitation intervention studies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Original Research",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Yujing Wang"
    },
    {
      "name": "Weilin Yin"
    },
    {
      "name": "Jie Zhang"
    },
    {
      "name": "Yifan Lin"
    },
    {
      "name": "Jie Jia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bhtvskfckngq7.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1988890",
  "fulltext_url": null,
  "id": "bhtvskfckngq7",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1988890",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/oncology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/bhtvskfckngq7.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T06:20:42Z",
      "native_id": "10.3389/fonc.2026.1988890",
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      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1988890"
    },
    {
      "first_seen": "2026-11-12T12:23:21Z",
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      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1988890/full"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Exploring the trajectory of quality-of-life deterioration associated with capecitabine-induced hand-foot syndrome and the optimal timing for rehabilitation intervention: secondary analysis of a randomized controlled trial",
  "title_text": "Exploring the trajectory of quality-of-life deterioration associated with capecitabine-induced hand-foot syndrome and the optimal timing for rehabilitation intervention: secondary analysis of a randomized controlled trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:20:48Z",
  "url": "https://research.draconitic.com/paper/bhtvskfckngq7",
  "venue": "Frontiers in Oncology",
  "versions": []
}