{
  "abstract": "Maximum lifespan varies widely among mammals, but the genomic basis of this variation remains incompletely understood. We used body-mass-corrected longevity and a phylogenetically informed phenotype-shift framework to compare 126 primate species, selecting seven long-lived and six short-lived species for convergent amino-acid substitution analysis. Stringent pooling across species identified 1,068 recurrent phenotype-associated positions in 934 genes. These genes showed significant agreement with mammal-wide longevity candidates, with 226 genes shared compared with 120 expected by chance (1.88-fold enrichment; P = 1.16 x 10exp-22). Functional analysis detected 17 significant terms, with the strongest coherent signal involving male infertility and decreased male fertility. Our results show that focused primate sampling recovers a non-random component of the broader mammalian longevity signal and point to male reproductive biology as a promising direction for investigating the evolution of lifespan.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Evolutionary Biology (IBE, UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona (P"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "F. Barteri"
    },
    {
      "name": "M. Ramon"
    },
    {
      "name": "E. Brigos"
    },
    {
      "name": "D. Juan"
    },
    {
      "name": "G. Muntane"
    },
    {
      "affs": [
        0
      ],
      "name": "A. Navarro"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bj3jetp2hvdv3.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.04.749475",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749475v1.full",
  "id": "bj3jetp2hvdv3",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749475v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "evolutionary biology"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7212159361",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749475v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bj3jetp2hvdv3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:56Z",
      "native_id": "10.64898/2026.09.04.749475",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.04.749475v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:evolutionary biology",
      "subfield": "evolutionary-biology"
    }
  ],
  "title": "Convergent Amino-Acid Substitutions Link Primate Longevity to Male-Fertility Genes",
  "title_text": "Convergent Amino-Acid Substitutions Link Primate Longevity to Male-Fertility Genes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:56Z",
  "url": "https://research.draconitic.com/paper/bj3jetp2hvdv3",
  "venue": "bioRxiv",
  "versions": []
}