{
  "abstract": "Survival after radiofrequency ablation (RFA) for very early- or early-stage hepatocellular carcinoma (HCC) remains heterogeneous because prognosis depends on both tumor burden and hepatic reserve. We retrospectively evaluated treatment-naive patients with Barcelona Clinic Liver Cancer (BCLC) Stages 0 or A HCC treated with RFA as initial therapy from January 2002 to September 2016. Patients with Child-Pugh class A or B and complete ablation were included. Four prespecified total scores, Child-Pugh-tumor (CP-T), albumin-bilirubin-tumor (ALBI-T), modified ALBI-tumor (mALBI-T), and platelet-ALBI-tumor (pALBI-T) were compared using the Akaike information criterion (AIC), Harrell concordance index (C-index), time-dependent area under the receiver operating characteristic curve, calibration, and subgroup analyses. Of 1238 patients screened, 950 were included; 831 (87.5%) were Child-Pugh class A. During a median follow-up of 5.44 years, 417 deaths occurred; 5- and 10-year overall survival rates were 58.0% and 35.8%, respectively. The American Joint Committee on Cancer eighth-edition T stage illustrated the best tumor-stage performance and was used in the total scores, while mALBI-T had the lowest AIC (5052.2) and highest Harrell C-index (0.628; 95% confidence interval, 0.601-0.655). Paired bootstrap differences versus CP-T, ALBI-T, and pALBI-T were statistically significant, but modest, while mALBI-T performed best at 5 years and in Child-Pugh class A patients, whereas all models showed limited discrimination in Child-Pugh class B patients. Apparent calibration was generally close, and mALBI-T also had the best fit for recurrence-free survival. mALBI-T provides a simple prognostic model for long-term survival stratification after complete ablation in early-stage hepatocellular carcinoma, especially in Child-Pugh class A patients.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung City, Taiwan.",
    "Division of Gastroenterology and Hepatology, E-Da Dachang Hospital, I-Shou University, Kaohsiung City, Taiwan.",
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jen-Ai Hospital, Taichung City, Taiwan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cheng-Ying Hsieh"
    },
    {
      "affs": [
        1
      ],
      "name": "Wen-Shuo Yeh"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi-Hao Yen",
      "orcid": "0000-0001-6251-7230"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan-Hung Kuo",
      "orcid": "0000-0003-0185-1846"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming-Chao Tsai",
      "orcid": "0000-0002-3613-2051"
    },
    {
      "affs": [
        2
      ],
      "name": "Sheng-Nan Lu",
      "orcid": "0000-0002-5493-4752"
    },
    {
      "affs": [
        0
      ],
      "name": "Chao-Hung Hung",
      "orcid": "0000-0003-1646-9519"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing-Houng Wang",
      "orcid": "0000-0002-4916-9814"
    },
    {
      "affs": [
        0
      ],
      "name": "Chien-Hung Chen",
      "orcid": "0000-0002-8896-8133"
    },
    {
      "affs": [
        0
      ],
      "name": "Kwong-Ming Kee",
      "orcid": "0000-0003-4836-4252"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bj3xq4cfczm4j.bib",
  "cited_by": 0,
  "doi": "10.1002/kjm2.70313",
  "fulltext_url": "https://europepmc.org/articles/PMC13728425",
  "id": "bj3xq4cfczm4j",
  "issns": [
    "1607-551X",
    "2410-8650"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972854",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2721|Hepatocellular Carcinoma Treatment and Prognosis"
    ]
  ],
  "openalex": "W7225138196",
  "pdf_url": "https://europepmc.org/articles/PMC13728425?pdf=render",
  "pmcid": "PMC13728425",
  "pmid": "42972854",
  "published": "2026-11-02",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/bj3xq4cfczm4j.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:43Z",
      "native_id": "MED:42972854",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972854"
    },
    {
      "first_seen": "2026-11-07T12:21:25Z",
      "native_id": "PMC13728425",
      "source": "pmc",
      "url": "https://doi.org/10.1002/kjm2.70313"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Hepatocellular Carcinoma Treatment and Prognosis",
      "subfield": "general"
    }
  ],
  "title": "Validation of Modified Albumin-Bilirubin-Tumor Stage as a Prognostic Model in Early-Stage Hepatocellular Carcinoma Treated With Radiofrequency Ablation.",
  "title_text": "Validation of Modified Albumin-Bilirubin-Tumor Stage as a Prognostic Model in Early-Stage Hepatocellular Carcinoma Treated With Radiofrequency Ablation.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:25Z",
  "url": "https://research.draconitic.com/paper/bj3xq4cfczm4j",
  "venue": "The Kaohsiung journal of medical sciences",
  "versions": []
}