{
  "abstract": "Night workers are chronically exposed to circadian disruption and melatonin suppression, conditions associated with an increased risk of cardiometabolic disorders. To determine whether exogenous melatonin administration impacts cardiometabolic parameters (glucose, glycated hemoglobin [HbA1c], insulin, total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], very low-density lipoprotein [VLDL], triglycerides, heart rates, and mean systolic and diastolic blood pressure) in overweight night workers without cardiometabolic abnormalities. A randomized, double-blind, placebo-controlled, crossover trial was conducted. Participants (n = 27) took 3 mg of fast-release melatonin or placebo orally for 3 months, 1 hour before bedtime, only on days off when they had nocturnal sleep, on an intermittent basis (every other day). Generalized estimating equations (GEEs) were used to analyze the cardiometabolic parameters. Systolic blood pressure showed a significant effect of time ( p = 0.01). Bonferroni-adjusted post-hoc comparisons showed higher values after placebo than at baseline (mean difference: 5.82 mmHg; 95%CI: 2.02-9.62; adjusted p = 0.01), whereas the difference between melatonin and placebo was not statistically significant (adjusted p = 1.00). No statistically significant effects of time were detected for the other cardiometabolic parameters. Melatonin was not associated with significant changes in cardiometabolic parameters compared with placebo in overweight night workers.",
  "abstract_shown": true,
  "affiliations": [
    "Pharmacy Department, Hospital Municipal de Cubatão, Cubatão, SPBrazil.",
    "Teaching and Research Laboratory, Sociedade Brasileira Caminho de Damasco, São Paulo, SPBrazil.",
    "Independent Research, São Paulo, SPBrazil.",
    "Department of Physiology, Intituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SPBrazil.",
    "Department of Health, Life Cycles, and Society, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SPBrazil.",
    "Stress Research Institute, University of Stockholm, StockholmSweden.",
    "Department of Public Health, Post-Graduate Program in Public Health, Escola de Saúde, Universidade Federal do Rio Grande do Norte, Natal, RNBrazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Patrícia Teixeira de Santana",
      "orcid": "0000-0003-0409-7973"
    },
    {
      "affs": [
        2
      ],
      "name": "Adriana de Sousa Duarte",
      "orcid": "0000-0002-0126-8557"
    },
    {
      "affs": [
        2
      ],
      "name": "Ananda Laís Felix Garrido",
      "orcid": "0000-0001-8847-1269"
    },
    {
      "affs": [
        2
      ],
      "name": "Pollyanna Pellegrino",
      "orcid": "0000-0003-3194-4082"
    },
    {
      "affs": [
        2
      ],
      "name": "Luciana Fidalgo Ramos Nogueira",
      "orcid": "0000-0002-0230-3684"
    },
    {
      "affs": [
        3
      ],
      "name": "José Cipolla-Neto",
      "orcid": "0000-0003-3748-3731"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Claudia Roberta de Castro Moreno",
      "orcid": "0000-0003-1839-9673"
    },
    {
      "affs": [
        4,
        6
      ],
      "name": "Elaine Cristina Marqueze",
      "orcid": "0000-0002-4987-7757"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bj9n8v629xpqe.bib",
  "cited_by": 0,
  "doi": "10.1055/s-0046-1829852",
  "fulltext_url": "https://europepmc.org/articles/PMC13743272",
  "id": "bj9n8v629xpqe",
  "issns": [
    "1984-0659",
    "1984-0063"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997745",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Communication"
    ],
    [
      "openalex",
      "2807|Circadian rhythm and melatonin"
    ]
  ],
  "openalex": "W7225408776",
  "pdf_url": "https://europepmc.org/articles/PMC13743272?pdf=render",
  "pmcid": "PMC13743272",
  "pmid": "42997745",
  "published": "2026-09-01",
  "publisher": "Brazilian Association of Sleep and Latin American Federation of Sleep",
  "ris": "https://research.draconitic.com/paper/bj9n8v629xpqe.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:42Z",
      "native_id": "MED:42997745",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997745"
    },
    {
      "first_seen": "2026-11-10T12:23:58Z",
      "native_id": "PMC13743272",
      "source": "pmc",
      "url": "https://doi.org/10.1055/s-0046-1829852"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Circadian rhythm and melatonin",
      "subfield": "physiology"
    }
  ],
  "title": "Intervention with Exogenous Melatonin Has No Adverse Effects on Cardiometabolic Parameters of Overweight Night Workers without Cardiometabolic Abnormalities.",
  "title_text": "Intervention with Exogenous Melatonin Has No Adverse Effects on Cardiometabolic Parameters of Overweight Night Workers without Cardiometabolic Abnormalities.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:23:58Z",
  "url": "https://research.draconitic.com/paper/bj9n8v629xpqe",
  "venue": "Sleep science (Sao Paulo, Brazil)",
  "versions": []
}