{
  "abstract": "Acute lung injury (ALI) is a severe inflammatory syndrome frequently complicated by brain injury, which worsens outcomes. Here, we explored whether regulation of the lung-brain axis represents a therapeutic strategy for the management of ALI. We show that intranasal administration of Fritillaria taipaiensis-derived exosome-like nanovesicles (Ft-ELNs) ameliorates LPS-induced ALI and ALI-associated hypothalamic inflammation in mice. Ft-ELNs preferentially accumulate in the lungs, inhibiting TRPV1 in both the lungs and the hypothalamus to establish the lung-brain axis. In parallel, Ft-ELNs primarily regulate systemic humoral immunity by inhibiting the VEGFR1/PI3K/AKT/NF?B signaling pathway. In vitro experiments further confirmed that Ft-ELNs are efficiently internalized by alveolar epithelial MLE-12 cells, exerting protective effects by suppressing VEGFR1 expression. Mechanistically, we identified Ft-miR1 of Ft-ELNs as the key functional effector that directly targets the Flt1 3'UTR to inhibit VEGFR1 expression. These data suggest that Ft-ELNs attenuate lung-brain axis inflammation by targeting VEGFR1 and may hold potential as novel therapeutic agents for the treatment of severe ALI.",
  "abstract_shown": true,
  "affiliations": [
    "Chengdu University of Traditional Chinese Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "H. Rao"
    },
    {
      "name": "J. Pan"
    },
    {
      "name": "J. Guo"
    },
    {
      "name": "X. Song"
    },
    {
      "name": "S. Gong"
    },
    {
      "name": "T. Zhou"
    },
    {
      "name": "Q. Wu"
    },
    {
      "name": "Y. Huang"
    },
    {
      "name": "W. Nie"
    },
    {
      "name": "C. Peng"
    },
    {
      "name": "Z. Li"
    },
    {
      "name": "C. Ren"
    },
    {
      "name": "J. Pei"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bjdrg2thv5yvf.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.07.749870",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749870v1.full",
  "id": "bjdrg2thv5yvf",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749870v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7212812998",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749870v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bjdrg2thv5yvf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:08Z",
      "native_id": "10.64898/2026.09.07.749870",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749870v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Intranasal Fritillaria taipaiensis nanovesicles alleviate acute lung injury via the lung-brain axis",
  "title_text": "Intranasal Fritillaria taipaiensis nanovesicles alleviate acute lung injury via the lung-brain axis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:08Z",
  "url": "https://research.draconitic.com/paper/bjdrg2thv5yvf",
  "venue": "bioRxiv",
  "versions": []
}