{
  "abstract": "Unlike other diseases where target organs for biopsy are accessible, surrogate platforms are warranted for biomarkers of neuropsychiatric disorders due to the inaccessibility of the brain. We demonstrate a non-invasive platform combining a nasal soft-brush swab with single-cell Western blotting for neuron-specific protein analysis. Applied to Alzheimer's disease targeting phosphorylated tau, this demonstrated superior diagnostic capacity compared with blood-based approaches, indicating that the olfactory neuroepithelium is a sensitive biomarker platform.",
  "abstract_shown": true,
  "affiliations": [
    "Johns Hopkins School of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "K. Ishizuka"
    },
    {
      "name": "G. Shang"
    },
    {
      "name": "S. Malik"
    },
    {
      "name": "C. Doty"
    },
    {
      "name": "S. Dave"
    },
    {
      "name": "N. Rowan"
    },
    {
      "name": "Y. Lema"
    },
    {
      "name": "A. Lane"
    },
    {
      "affs": [
        0
      ],
      "name": "A. Sawa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bjjm66aks0tnz.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.18.759991",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759991v1.full",
  "id": "bjjm66aks0tnz",
  "issns": [
    "2692-8205"
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  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759991v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biochemistry"
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    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7223055133",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759991v1.full.pdf",
  "pmcid": "PMC13738621",
  "pmid": "42995972",
  "published": "2026-10-18",
  "publisher": "Cold Spring Harbor Laboratory Preprints",
  "ris": "https://research.draconitic.com/paper/bjjm66aks0tnz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:44Z",
      "native_id": "10.64898/2026.10.18.759991",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759991v1"
    },
    {
      "first_seen": "2026-11-09T12:23:35Z",
      "native_id": "PMC13738621",
      "source": "pmc",
      "url": "https://doi.org/10.64898/2026.10.18.759991"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Olfactory neuroepithelium biomarker platform: a proof from Alzheimer's disease",
  "title_text": "Olfactory neuroepithelium biomarker platform: a proof from Alzheimer's disease",
  "type": "preprint",
  "updated_at": "2026-11-09T12:23:35Z",
  "url": "https://research.draconitic.com/paper/bjjm66aks0tnz",
  "venue": "bioRxiv",
  "versions": []
}