{
  "abstract": "Complex systems exhibit organization not only through their components but also via their interdependencies. Local nucleotide dependencies underpin regulatory motifs and RNA structures, yet principles governing a higher-order organization across the human genome remain unknown. Here we systematically perturbed every position of the com- plete telomere-to-telomere human genome using Nucleotide Transformer v3 with an ex- ascale compute cluster, generating nucleotide-resolution dependency maps that reveal a directed, weighted network of position-to-position genomic relationships. This network recapitulates known biological features and uncovers recurrent, directional architec- tures termed 'relons', spanning coding, non-coding, and unannotated regions. These re- lational modules reflect evolutionary and functional constraints and associate with hu- man genetic variation and pathogenic variants. Our findings suggest a higher-order rela- tional layer of genome organization, providing a framework to interpret DNA as a complex system of dependencies beyond linear and 3D structure, with implications for under- standing genetic variation and disease.",
  "abstract_shown": true,
  "affiliations": [
    "RWTH Aachen, University Hospital"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "I. Kurth"
    },
    {
      "name": "J. Krause"
    },
    {
      "name": "M. Danner"
    },
    {
      "name": "F. Kraft"
    },
    {
      "name": "T. Islam"
    },
    {
      "name": "M. Begemann"
    },
    {
      "name": "Z. Ziad"
    },
    {
      "name": "M. Elbracht"
    },
    {
      "name": "M. Bode"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bjxmx31gfhhjn.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.15.759350",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759350v1.full",
  "id": "bjxmx31gfhhjn",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759350v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "genomics"
    ],
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W7222720957",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759350v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bjxmx31gfhhjn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:06Z",
      "native_id": "10.64898/2026.10.15.759350",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759350v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:genomics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "A relational architecture of the human genome",
  "title_text": "A relational architecture of the human genome",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:11Z",
  "url": "https://research.draconitic.com/paper/bjxmx31gfhhjn",
  "venue": "bioRxiv",
  "versions": []
}