{
  "abstract": "BACKGROUND: The interventricular septum contributes 30-60% of right ventricular (RV) output. However, few studies have assessed the prognostic value of RV septal strain in pulmonary embolism (PE). We hypothesized that RV septal strain would predict 30-day mortality in patients with intermediate-risk PE. METHODS AND RESULTS: This retrospective cohort study analyzed consecutive patients with intermediate-risk PE admitted to the Penn State Health Milton S. Hershey Medical Center between 2010 and 2018. The primary outcome was 30-day all-cause mortality. RV septal strain was measured within the RV endocardium and was defined as the mean of basal, mid, and apical septal longitudinal strain. Among 251 patients, 31 (12.4%) died within 30 days of PE diagnosis. RV strain analysis was feasible in 230 (91.6%) patients. RV septal strain was significantly lower in those who died and was independently associated with 30-day mortality (P<0.001). Receiver operating characteristic curve analysis indicated 14.4% as the optimal RV septal strain cut-off value (area under the curve 0.816). Kaplan-Meier curves demonstrated that 30-day mortality risk was higher among patients with low (≤14.4%) than high (>14.4%) RV septal strain (hazard ratio 9.29; P<0.001). CONCLUSIONS: RV septal strain is a feasible and reproducible parameter with strong prognostic value in patients with intermediate-risk PE. These findings highlight the central role of the interventricular septum in RV function and risk stratification.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Ayumi Eguchi"
    },
    {
      "name": "Shunsuke Eguchi"
    },
    {
      "name": "Yoshiyuki Orihara"
    },
    {
      "name": "Michael Pfeiffer"
    },
    {
      "name": "Brandon Peterson"
    },
    {
      "name": "Mohammed Ruzieh"
    },
    {
      "name": "John Boehmer"
    },
    {
      "name": "John Gorcsan III"
    },
    {
      "name": "Ryan Wilson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bk1tnaq9b3ywe.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-25-1133",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1133/_article",
  "id": "bk1tnaq9b3ywe",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1133/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2724|Venous Thromboembolism Diagnosis and Management"
    ]
  ],
  "openalex": "W7161004944",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bk1tnaq9b3ywe.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-25-1133",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1133/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "jstage-journal:medicine/cardiovascular",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Prognostic Value of Right Ventricular Septal Longitudinal Strain in Intermediate-Risk Pulmonary Embolism",
  "title_text": "Prognostic Value of Right Ventricular Septal Longitudinal Strain in Intermediate-Risk Pulmonary Embolism",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/bk1tnaq9b3ywe",
  "venue": "Circulation Journal",
  "versions": []
}