{
  "abstract": "Stimulator of interferon genes (STING) agonists have shown limited antitumor efficacy, in part because STING activation is not preferentially focused on dendritic cells (DCs), which specialize in cross-priming. We present a DC-centric strategy that synergistically licenses DCs by coordinating CD47-SIRPα checkpoint relief and STING activation via dual ultra-pH-sensitive gating. Mild tumor acidity first unmasks the αCD47 cue to prime antigen acquisition. Following DC-biased uptake, a second acidic gate releases cGAMP to engage STING in antigen-bearing DCs. Functionally, efficacy requires Batf3-dependent cDC1s and CD8+ T cells, yet is preserved after macrophage depletion. In murine models, this strategy suppresses tumor growth and metastasis with good tolerability, and it retains activity in a humanized cell-line-derived xenograft model established in NSG-SGM3 hosts, supporting activity in a partially reconstituted human immune setting. Together, this work presents a mechanism-guided combination strategy to optimize STING agonist therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmaceutics, Jiang Su Key Laboratory of Drug Design and Optimization, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China",
    "School of Medicine, Nankai University, Tianjin 300071, China",
    "Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China",
    "Tianjin Central Hospital of Obstetrics and Gynecology/Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin 300100, China",
    "State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, P.R. China",
    "Haihe Laboratory of Cell Ecosystem, Tianjin 300100, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuting Xiang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Shanshan Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Tuzhi Xu"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenwen Yu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiefu Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Xin You"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengjia Chai"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaohu Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Xiaoliang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Junmei Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Junjia Liu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Xiubao Ren"
    },
    {
      "affs": [
        2
      ],
      "name": "Weijie Song"
    },
    {
      "affs": [
        2
      ],
      "name": "Tingting Qin"
    },
    {
      "affs": [
        0
      ],
      "name": "Suxin Li"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Jian Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bk5q8knbgax89.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103025",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710145/",
  "id": "bk5q8knbgax89",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103025",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
    ]
  ],
  "openalex": "W7211912265",
  "pdf_url": null,
  "pmcid": "PMC13710145",
  "pmid": "42705236",
  "published": "2026-09-07",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/bk5q8knbgax89.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:10Z",
      "native_id": "PMC13710145",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103025"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
    }
  ],
  "title": "Dendritic cell centric nanoengineering couples antigen acquisition and STING activation for cancer immunotherapy",
  "title_text": "Dendritic cell centric nanoengineering couples antigen acquisition and STING activation for cancer immunotherapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:10Z",
  "url": "https://research.draconitic.com/paper/bk5q8knbgax89",
  "venue": "Cell Reports Medicine",
  "versions": []
}