{
  "abstract": "Herein, we report a transition metal-free synthesis of monofluoroalkenes via a C-F bond reconstruction approach. The process employs inexpensive BF3·Et2O as a catalyst for the stereoselective intermolecular fluoroacylation of unactivated alkynes with alkyl/aryl acid fluorides to access various monofluoroalkene products (24 examples, typically >98:<2 Z:E). The synthetic utility of the products was demonstrated via their conversion into various heterocycles (pyrazoles, isoxazoles, and pyrimidines) and fluoroalkene-containing esters/amides.",
  "abstract_shown": true,
  "affiliations": [
    "Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Translational Research Hub, CardiffCF24 4HQ, United Kingdom.",
    "School of Chemistry, Cardiff University, Main Building, Park Place, CardiffCF10 3AT, United Kingdom.",
    "Department of Chemistry, College of Science, University of Jeddah, Jeddah21589, Kingdom of Saudi Arabia.",
    "Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, Jizan45142, Kingdom of Saudi Arabia.",
    "Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, MacclesfieldSK10 2NA, United Kingdom.",
    "Department of Chemistry, University of Bath, Claverton Down, BathBA2 7AY, United Kingdom."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tanmay Kanji"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Asma A Alharthi"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Abdulrahman H Husayni"
    },
    {
      "affs": [
        4
      ],
      "name": "Pippa Wainwright"
    },
    {
      "affs": [
        1
      ],
      "name": "Thomas Wirth"
    },
    {
      "affs": [
        0
      ],
      "name": "Rebecca L Melen",
      "orcid": "0000-0003-3142-2831"
    },
    {
      "affs": [
        5
      ],
      "name": "Louis C Morrill",
      "orcid": "0000-0002-6453-7531"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bk609cyggcv0c.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03620",
  "fulltext_url": "https://europepmc.org/articles/PMC13660379",
  "id": "bk609cyggcv0c",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912214",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7214535528",
  "pdf_url": "https://europepmc.org/articles/PMC13660379?pdf=render",
  "pmcid": "PMC13660379",
  "pmid": "42912214",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bk609cyggcv0c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42912214",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912214"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Catalytic Stereoselective Intermolecular Fluoroacylation of Unactivated Alkynes via C-F Bond Reconstruction.",
  "title_text": "Catalytic Stereoselective Intermolecular Fluoroacylation of Unactivated Alkynes via C-F Bond Reconstruction.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/bk609cyggcv0c",
  "venue": "Organic letters",
  "versions": []
}