{
  "abstract": "Diabetic patients exhibit delayed skin wound healing due to chronic hyperglycemia, which results in prolonged tissue recovery. In this work, a skin dressing was synthesized using three natural composites: chitosan, gelatin, and Zingiber officinale herb, commonly known as ginger (CH+GE+ZO). The dressing was applied to albino Wistar rats, which then received an intraperitoneal injection of Alloxan at a dose of 150 mg/kg. Incision caused skin wounds. The antioxidant markers were quantified. A histological study was conducted to evaluate the effectiveness of the skin healing process. Analysis of the oxidative balance revealed a significant (p < .001) increase in enzymatic antioxidant activities in the CH+GE+ZO-treated group compared to the diabetic group. A considerable increase in non-enzymatic markers was observed compared to the diabetic group (p < .001). Histologically, the application of a composite synthesized by CH+GE+ZO dressing showed an improvement in the healing process, compared to controls, and a total recovery of wounds was observed around Day 13. This was characterized by a progressive reepithelialization, a structured organization of the layers of the epidermis, as well as a partial restoration of the cutaneous appendages. Overall, the synthesized biological dressing actively contributes to tissue repair and skin healing.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Mabrouka Ghabbari"
    },
    {
      "name": "Awatef Elwej"
    },
    {
      "name": "Taysir Ghabbari"
    },
    {
      "name": "Ghada Ben Salah"
    },
    {
      "name": "Amal Ahmed Ismail"
    },
    {
      "name": "Hassane Oudadesse"
    },
    {
      "name": "Samira Jebahi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bk64v4e20fmnj.bib",
  "cited_by": 0,
  "doi": "10.1177/22313354261438281",
  "fulltext_url": null,
  "id": "bk64v4e20fmnj",
  "issns": [
    "2231-3354"
  ],
  "landing_url": "https://hal.science/hal-05834638v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7203440097",
  "pdf_url": "https://hal.science/hal-05834638/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "MediPoeia",
  "ris": "https://research.draconitic.com/paper/bk64v4e20fmnj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "hal-05834638",
      "source": "hal",
      "url": "https://hal.science/hal-05834638v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Development and Assessment of a Zingiber officinale -based Biologic Dressing for Enhanced Wound Healing in Diabetic Rats",
  "title_text": "Development and Assessment of a Zingiber officinale -based Biologic Dressing for Enhanced Wound Healing in Diabetic Rats",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:00Z",
  "url": "https://research.draconitic.com/paper/bk64v4e20fmnj",
  "venue": "Journal of Applied Pharmaceutical Science",
  "versions": []
}