{
  "abstract": "Multiple symmetric lipomatosis (MSL) is a rare adipose tissue disease characterized by progressive, non-encapsulated, symmetrical fat accumulation. Its pathophysiology is still not completely understood. Here, we performed the first intraindividual comparison of secretomes of human adipose-derived stem cells (hASCs) isolated from affected and unaffected regions of n = 15 patients (proteomic discovery cohort n = 5). Affected MSL-hASCs tend to show accelerated metabolic signals and higher cell densities with preserved adipogenic differentiation capacity. Secretome transfer of affected MSL-hASCs significantly increased metabolic activity of wt-hASCs after 24 h in 4/7 samples (all explorative Benjamini-Hochberg corrected p = 0.040). Bottom-up proteomic analysis identified 811 proteins, of which 220 were classified as secreted. Thirteen proteins exhibited nominally significant dysregulation of expression, including CALR ( p = 0.0061), LAMC1 ( p = 0.0241), S100A7 ( p = 0.0281) and HDGF ( p = 0.0474), but none remained significant after application of the Benjamini-Hochberg (BH) correction to control the False Discovery Rate (FDR) at 0.05. Transcriptional validation by rt-qPCR revealed a trend toward downregulation of hLAMA4 and hCFB (both p = 0.0625). In conclusion, convergent patterns are consistent with extracellular matrix remodeling and PI3K/AKT-ERK-associated proliferative signaling. This model supports a hypothesis of progenitor-level dysregulation rather than a single clonal driver in MSL, which will require further mechanistic validation in larger cohorts.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Ruben Reinhard"
    },
    {
      "name": "Oliver Felthaus"
    },
    {
      "name": "Andreas Siegmund"
    },
    {
      "name": "Katharina Limm"
    },
    {
      "name": "Peter J. Oefner"
    },
    {
      "name": "Marc Ruewe"
    },
    {
      "name": "Silvan Eisenmann"
    },
    {
      "name": "Christian Festbaum"
    },
    {
      "name": "Lukas Prantl"
    },
    {
      "name": "Dmytro Oliinyk",
      "orcid": "0009-0000-7662-2189"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bkdav0jczdry0.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-74618-w",
  "fulltext_url": null,
  "id": "bkdav0jczdry0",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-74618-w",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Mesenchymal stem cell research"
    ]
  ],
  "openalex": "W7221334598",
  "pdf_url": "https://www.nature.com/articles/s41598-026-74618-w.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/bkdav0jczdry0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:25Z",
      "native_id": "10.1038/s41598-026-74618-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-74618-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Mesenchymal stem cell research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Pilot intraindividual secretome profiling of adipose-derived stem cells in multiple symmetric lipomatosis",
  "title_text": "Pilot intraindividual secretome profiling of adipose-derived stem cells in multiple symmetric lipomatosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:25Z",
  "url": "https://research.draconitic.com/paper/bkdav0jczdry0",
  "venue": "Scientific Reports",
  "versions": []
}