{
  "abstract": "Objectives\n\nAntineutrophil cytoplasmic antibody-associated vasculitis (AAV) is associated with increased cardiovascular risk, related to persistent inflammation and endothelial dysfunction. Long-term systolic blood pressure variability (SBPV), reflecting vascular damage, may predict outcomes better than mean blood pressure (BP). We investigated the impact of BP control and visit-to-visit BP variability (VVV), on all-cause mortality in AAV patients during maintenance therapy.Methods\n\nWe retrospectively studied 95 AAV patients followed at three Italian nephrology centers. SBPV was defined as the standard deviation of ≥4 systolic BP measurements within 12 months from the first SBPV assessment. Patients were stratified by SBPV tertiles. The primary outcome was all-cause mortality.Results\n\nOver a median follow-up of 78 months, 14 patients (14.7%) died. Deceased patients were older and had higher pulse pressure (PP) and VVV. Hypertension prevalence increased across SBPV tertiles (35%, 62%, 69%; P = .02). Mortality rose from 6% in the lowest to 34.5% in the highest SBPV tertile (Fisher's exact, P = .001). Time-averaged systolic BP was not associated with mortality. Conversely, each 5-mmHg increase in SBPV was associated with a two-fold higher risk of death [hazard ratio (HR) 2.03, 95% confidence interval (CI) 1.29-3.20; P = .002]. SBPV remained significantly associated with outcome after full multi-variable adjustment, including age, sex, myeloperoxidase positivity, estimated glomerular filtration rate, PP, and proteinuria (adjusted HR 8.06 per 1 mmHg, 95% CI 1.42-45.54; P = .02).Conclusion\n\nIn AAV patients, increased VVV was associated with all-cause mortality outperforming mean systolic BP. Further research is needed to confirm the impact of variable blood pressure on patient outcomes in AAV.",
  "abstract_shown": true,
  "affiliations": [
    "Nephrology, dialysis and Transplantation Unit, IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy.",
    "Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Genova, Italy.",
    "Nephrology Unit, Università degli Studi di Brescia-ASST Spedali Civili di Brescia, Brescia, Italy.",
    "Nephrology and Dialysis Division, IRCCS Humanitas Research Hospital, Milano, Italy.",
    "Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elisabetta Bussalino"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elisa Russo",
      "orcid": "0000-0003-1279-3178"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lucia Maccio"
    },
    {
      "affs": [
        1
      ],
      "name": "Marta Donati"
    },
    {
      "affs": [
        2
      ],
      "name": "Federica Mescia"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Marta Calatroni"
    },
    {
      "affs": [
        2
      ],
      "name": "Martina Tedesco",
      "orcid": "0009-0004-4375-4942"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Gabriella Moroni"
    },
    {
      "affs": [
        2
      ],
      "name": "Federico Alberici",
      "orcid": "0000-0002-1686-5709"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Francesca Viazzi",
      "orcid": "0000-0003-4219-7043"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pasquale Esposito",
      "orcid": "0000-0002-0834-5586"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bkgqa9rz2a5aw.bib",
  "cited_by": 0,
  "doi": "10.1093/ckj/sfag356",
  "fulltext_url": "https://europepmc.org/articles/PMC13678739",
  "id": "bkgqa9rz2a5aw",
  "issns": [
    "2048-8505",
    "2048-8513"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899105",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Blood Pressure and Hypertension Studies"
    ]
  ],
  "openalex": "W7220833807",
  "pdf_url": "https://europepmc.org/articles/PMC13678739?pdf=render",
  "pmcid": "PMC13678739",
  "pmid": "42899105",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bkgqa9rz2a5aw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42899105",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899105"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Blood Pressure and Hypertension Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Blood pressure variability associates with mortality risk of patients with ANCA-associated vasculitis.",
  "title_text": "Blood pressure variability associates with mortality risk of patients with ANCA-associated vasculitis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/bkgqa9rz2a5aw",
  "venue": "Clinical kidney journal",
  "versions": []
}