{
  "abstract": "Background: Age-related macular degeneration (AMD) is a leading cause of vision impairment globally and demonstrates substantial variation regarding progression and clinical subtypes across populations. This paper describes the methodology of our study, designed to establish the natural history of AMD in Asian elderly and to identify predictors of progression from early signs of AMD to late AMD over a 5-year period. Methods: This prospective, longitudinal cohort study aims to recruit 1500 participants from community-based cohorts in Singapore, with a follow-up duration of 5 years. Eligible participants are adults aged 55 years or older without severe systemic illness that would preclude participation. Discussion: There is a paucity of data on the progression of AMD and optimal referral thresholds, particularly in Asian populations. This community-based cohort, representative of the general population, will generate one of the largest longitudinal datasets on AMD in Asia and aims to inform future screening strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Singapore Eye Research Institute, Singapore National Eye Centre, Singapore",
    "Duke-NUS Eye ACP, National University of Singapore, Singapore",
    "Singapore General Hospital, Singapore",
    "Centre for Public Health, Faculty of Medicine and Health Sciences, Queen’s University Belfast, Belfast, United Kingdom"
  ],
  "article_type": "Study Protocol",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ali Forouhari"
    },
    {
      "affs": [
        1
      ],
      "name": "Chui Ming Gemmy Cheung"
    },
    {
      "affs": [
        2
      ],
      "name": "Low Lian Leng"
    },
    {
      "affs": [
        3
      ],
      "name": "Noa Gilead"
    },
    {
      "name": "Usha Chakravarthy"
    },
    {
      "name": "Kelvin Yi Chong Teo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bmbtvdr9vjjea.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0355953",
  "fulltext_url": null,
  "id": "bmbtvdr9vjjea",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0355953",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Retinal Diseases and Treatments"
    ],
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      "plos",
      "/Biology and life sciences/Anatomy/Head/Eyes"
    ],
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      "plos",
      "/Biology and life sciences/Anatomy/Ocular system/Eyes"
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      "plos",
      "/Biology and life sciences/Anatomy/Ocular system/Ocular anatomy/Fovea centralis"
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      "plos",
      "/Biology and life sciences/Biochemistry/Biomarkers"
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      "/Medicine and health sciences/Anatomy/Head/Eyes"
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      "/Medicine and health sciences/Geriatrics/Geriatric ophthalmology/Macular degeneration"
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      "/Medicine and health sciences/Medical conditions/Eye diseases/Retinal disorders/Macular disorders/Macular degeneration"
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      "plos",
      "/Medicine and health sciences/Medical conditions/Eye diseases/Retinal disorders/Retinal degeneration/Macular degeneration"
    ],
    [
      "plos",
      "/Medicine and health sciences/Ophthalmology/Eye diseases/Retinal disorders/Macular disorders/Macular degeneration"
    ],
    [
      "plos",
      "/Medicine and health sciences/Ophthalmology/Eye diseases/Retinal disorders/Retinal degeneration/Macular degeneration"
    ],
    [
      "plos",
      "/Medicine and health sciences/Ophthalmology/Geriatric ophthalmology/Macular degeneration"
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      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Tomography"
    ],
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      "/People and places/Geographical locations/Asia/Singapore"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0355953&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/bmbtvdr9vjjea.ris",
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    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "10.1371/journal.pone.0355953",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0355953"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:diagnostic radiology",
      "subfield": "imaging"
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    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Predicting risk of progression of early to late AMD in the aging eye through imaging and multimodal evaluation: PRIME study protocol",
  "title_text": "Predicting risk of progression of early to late AMD in the aging eye through imaging and multimodal evaluation: PRIME study protocol",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/bmbtvdr9vjjea",
  "venue": "PLOS One",
  "versions": []
}