{
  "abstract": "Sofosbuvir is a pronucleotide prodrug (ProTide) that releases a uridine monophosphate analogue, which could modify proteins chemically or through UMP-transferring enzymes. Using an alkyne-tagged probe and chemical proteomics, we identified about 120 labelled proteins and a UMPylation-like (+774.31 Da) modification on cathepsin Z, suggesting that nucleotide prodrugs may enter protein nucleotidylation pathways.",
  "abstract_shown": true,
  "affiliations": [
    "LMU Munich, Department of Chemistry"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "M. Hertwig"
    },
    {
      "affs": [
        0
      ],
      "name": "P. Kielkowski"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bmtc6h1f9thdv.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.17.759838",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.17.759838v1.full",
  "id": "bmtc6h1f9thdv",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.17.759838v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biochemistry"
    ],
    [
      "openalex",
      "1605|Click Chemistry and Applications"
    ]
  ],
  "openalex": "W7223033493",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.17.759838v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bmtc6h1f9thdv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:41Z",
      "native_id": "10.64898/2026.10.17.759838",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.17.759838v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Click Chemistry and Applications",
      "subfield": "organic"
    }
  ],
  "title": "Chemical proteomics suggests sofosbuvir is metabolically attached to proteins through a UMPylation-like pathway.",
  "title_text": "Chemical proteomics suggests sofosbuvir is metabolically attached to proteins through a UMPylation-like pathway.",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:41Z",
  "url": "https://research.draconitic.com/paper/bmtc6h1f9thdv",
  "venue": "bioRxiv",
  "versions": []
}