{
  "abstract": "The current comprehensive treatment system for colorectal cancer (CRC), which is primarily based on surgery and supplemented by chemotherapy, radiotherapy, and targeted therapy, still faces several bottlenecks, including significant toxic side effects of chemotherapeutic agents, reduced chemosensitivity due to multiple drug resistance (MDR) mechanisms, and dependence of targeted therapy on specific gene mutations, resulting in limited overall efficacy. Nanocarriers, through strategies such as active targeting modifications, tumor microenvironment-responsive drug release, and co-loading of multiple therapeutic agents, can partially overcome the insufficient penetration efficiency of passive targeting imposed by the dense stromal barrier of tumor tissues, thereby offering a novel pathway for precision drug delivery distinct from conventional passive targeting approaches. This review systematically summarizes the research progress of various nanocarriers in CRC therapy, analyzes common factors hindering clinical translation based on translational data from representative nanomedicine formulations, and proposes future directions from perspectives including molecular subtype-guided individualized design, oral targeted delivery, and multimodal combination therapy, with the aim of providing references for both fundamental research and clinical translation of nanodrug delivery systems for CRC.",
  "abstract_shown": true,
  "affiliations": [
    "First Clinical Medical College, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China",
    "Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qin Guangquan"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen Lifa"
    },
    {
      "affs": [
        0
      ],
      "name": "Luo Deyan"
    },
    {
      "affs": [
        0
      ],
      "name": "Qin Hancheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Guo Yun"
    },
    {
      "affs": [
        0
      ],
      "name": "Huang Jiahao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bmxj17r57yx71.bib",
  "cited_by": 0,
  "doi": "10.19668/j.cnki.issn1674-0491.2026.04.017",
  "fulltext_url": "https://jcas.gxmuyfy.cn/en/wqll/paper.html?id=922293835558686720&cateName=Vol.4%20%20No.32%202026",
  "id": "bmxj17r57yx71",
  "issns": [
    "1674-0491"
  ],
  "landing_url": "https://doi.org/10.19668/j.cnki.issn1674-0491.2026.04.017",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RD1-811"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7223656019",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": "Editorial Office of Journal of Colorectal & Anal Surgery",
  "ris": "https://research.draconitic.com/paper/bmxj17r57yx71.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:27Z",
      "native_id": "0ddbfb20291a4f8480d62721d96eb1bd",
      "source": "doaj",
      "url": "https://doi.org/10.19668/j.cnki.issn1674-0491.2026.04.017"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Advances in the application of nanocarriers in colorectal cancer treatment",
  "title_text": "Advances in the application of nanocarriers in colorectal cancer treatment",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:20Z",
  "url": "https://research.draconitic.com/paper/bmxj17r57yx71",
  "venue": "结直肠肛门外科",
  "versions": []
}