{
  "abstract": "Background Pregnant women with systemic lupus erythematosus (SLE) are at high risk of preeclampsia (PE). However, overlapping clinical features between the two conditions make it challenging to detect superimposed PE. Failure to promptly recognize PE significantly increases the risk of adverse pregnancy outcomes. In recent years, complete blood count–derived inflammatory indicators (e.g., platelet-to-lymphocyte ratio) have emerged as readily available, low-cost biomarkers with clinical utility. This study aimed to assess the discriminative capacity of these derived inflammatory indicators, measured within one week before delivery, for identifying superimposed PE in pregnant patients with SLE. Methods This retrospective single-center study included 157 pregnant women with SLE treated at Nanfang Hospital of Southern Medical University from April 2010 to October 2024. Clinical and laboratory data, including complete blood count, liver function tests, and coagulation parameters, were collected. Univariate and multivariate logistic regression were performed to identify risk factors for PE and construct combined models. Model performance was assessed using receiver operating characteristic (ROC) curves, Hosmer–Lemeshow test, calibration plots, and the integrated discrimination improvement (IDI) and net reclassification improvement (NRI) indices. Internal validation used the bootstrap method, and sensitivity analysis used E-values. Results Among the study patients, 35 developed PE. Univariate logistic regression analysis showed significant differences in monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) between groups (P < 0.05). Multivariable logistic regression identified that lower MLR (OR = 0.223, 95% CI: 0.071–0.699) and PLR (OR = 0.344, 95% CI: 0.175–0.675) levels may be associated with an increased risk of superimposed PE in SLE pregnancies. The models based on MLR (AUC = 0.859, 95% CI: 0.782–0.936) and PLR (AUC = 0.860, 95% CI: 0.786–0.934) each showed discriminative capacity for identifying PE in pregnant patients with SLE. Conclusion MLR and PLR may serve as cost-effective and readily available markers for identifying superimposed preeclampsia in pregnant patients with SLE. These preliminary findings warrant validation in larger prospective cohorts, given the small sample size.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology, School of Public Health, Southern Medical University",
    "Reproductive Medicine Center, The Eighth Affiliated Hospital, Southern Medical University (The First People’s Hospital of Shunde)",
    "Sanshui District Center for Disease Control and Prevention",
    "Institute of Nephrology, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University",
    "Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University",
    "Department of Obstetrics, Dongguan Maternal and Child Health Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiaxin Huo"
    },
    {
      "affs": [
        0
      ],
      "name": "Minyi Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Haoyue Hu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yinghua Xu"
    },
    {
      "affs": [
        3
      ],
      "name": "Shujie Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Jun Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Jiayi Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Sishi Song"
    },
    {
      "affs": [
        5
      ],
      "name": "Manna Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Guifang Hu"
    },
    {
      "affs": [
        4
      ],
      "name": "Mei Zhong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bncgkpq5etgf9.bib",
  "cited_by": 0,
  "doi": "10.1186/s12884-026-09681-2",
  "fulltext_url": "https://doi.org/10.1186/s12884-026-09681-2",
  "id": "bncgkpq5etgf9",
  "issns": [
    "1471-2393"
  ],
  "landing_url": "https://doi.org/10.1186/s12884-026-09681-2",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RG1-991"
    ],
    [
      "openalex",
      "2729|Pregnancy and preeclampsia studies"
    ]
  ],
  "openalex": "W7169869394",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/bncgkpq5etgf9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:33Z",
      "native_id": "5bc20e26919e4c448fecc4aa05e18e62",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12884-026-09681-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Pregnancy and preeclampsia studies",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Derived inflammatory indicators for identifying preeclampsia in pregnant patients with systemic lupus erythematosus: a case–control study",
  "title_text": "Derived inflammatory indicators for identifying preeclampsia in pregnant patients with systemic lupus erythematosus: a case–control study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:33Z",
  "url": "https://research.draconitic.com/paper/bncgkpq5etgf9",
  "venue": "BMC Pregnancy and Childbirth",
  "versions": []
}