{
  "abstract": "Background: Radish red anthocyanins (RRA) extract, derived from geographical-indication Yanzhi radish from Fuling, Chongqing, China, was investigated to attenuate high-fat diet- induced aging in Drosophila melanogaster. RRA extract, rich in acylated pelargonidin- and cyanidin-based anthocyanins, extended lifespan without reducing food intake, improved reproductive and locomotor performance, raised superoxide dismutase and catalase activities, whereas reduced malondialdehyde accumulation. Mthoths: Using a Drosophila melanogaster model, we investigated the anti-aging effects of RRA extract and its potential underlying mechanisms. Results: It enhanced resistance to starvation, cold, and heat stress, reduced age-associated intestinal leakage, and regulated antioxidant- and autophagy-related genes, particularly manganese superoxide dismutase (SOD2) and autophagy-related 8a (Atg8a). Gut microbiota analysis showed high-dose RRA supplementation selectively increased Pseudomonas-related amplicon sequence variants 30 and 31. Untargeted metabolomics showed variations in glycerophospholipid, sphingolipid, nucleotide, and amino acid metabolism. Correlation results linked these Pseudomonas-related bacteria with lipid/nucleotide-related metabolites and stress resistance. Conclusions: RRA extract alleviated diet-induced aging through antioxidant defense, intestinal protection, and gut microbiota–metabolite modulation, providing a research basis for high-value utilization of Yanzhi radish anthocyanins.",
  "abstract_shown": true,
  "affiliations": [
    "College of Food Science, Southwest University, No. 2 Tiansheng Road, Chongqing 400715, China",
    "Southeast Chongqing Academy of Agricultural Sciences, Fuling Academy of Southwest University, Chongqing 408000, China",
    "School of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhenxia Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Can Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingjing Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Fayin Ye",
      "orcid": "0000-0001-7726-7596"
    },
    {
      "affs": [
        1
      ],
      "name": "Fasheng Lv"
    },
    {
      "affs": [
        1
      ],
      "name": "Cai Peng"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhenyu Chen",
      "orcid": "0000-0001-5615-1682"
    },
    {
      "affs": [
        0
      ],
      "name": "Lin Lei",
      "orcid": "0000-0003-3304-6243"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bnt2w4vgq0xyf.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18213499",
  "fulltext_url": null,
  "id": "bnt2w4vgq0xyf",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://www.mdpi.com/2072-6643/18/21/3499",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7223703880",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/bnt2w4vgq0xyf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:56Z",
      "native_id": "10.3390/nu18213499",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/21/3499"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "Radish Red Anthocyanins Extract Attenuated High-Fat Diet-Induced Aging in Association with Improving Antioxidant Defense and Gut Microbiota–Metabolite Changes in Drosophila Melanogaster",
  "title_text": "Radish Red Anthocyanins Extract Attenuated High-Fat Diet-Induced Aging in Association with Improving Antioxidant Defense and Gut Microbiota–Metabolite Changes in Drosophila Melanogaster",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:56Z",
  "url": "https://research.draconitic.com/paper/bnt2w4vgq0xyf",
  "venue": "Nutrients",
  "versions": []
}