{
  "abstract": "Background: Residual microorganisms within dentinal tubules remain a key factor in persistent endodontic infections. Therefore, the ability of intracanal medicaments to effectively penetrate these tubules is critical for post-endodontic treatment success and effective long-term prognosis. Aim: To evaluate and compare the dentinal tubule penetration capabilities of a novel nano calcium hydroxide–zinc oxide (NCAL + ZnO) formulation with conventional calcium hydroxide (RC CAL) and triple antibiotic paste (TAP) using confocal laser scanning microscopy (CLSM). Materials and methods: Forty-five extracted single-rooted human teeth were biomechanically prepared using standardized protocols and randomly allocated into three groups (n = 15). Medicaments were labelled with rhodamine B and placed into root canals. Samples were sectioned at coronal, middle, and apical thirds and analyzed using CLSM. Penetration depth (μm) was measured and analyzed using one-way ANOVA and Tukey post hoc test (p < 0.05). Results: RC CAL demonstrated the greatest penetration depths in the coronal and middle thirds, while NCAL + ZnO was the only material showing penetration in the apical third. All intergroup differences were statistically significant (p < 0.001). Conclusion: The novel nano Ca(OH) 2 –ZnO formulation showed a distinct advantage in apical penetration, suggesting potential clinical relevance for improving disinfection in anatomically challenging apical regions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, PH Road, Chennai, 600077, Tamil Nadu, India",
    "Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, PH Road, Chennai, 600077, Tamil Nadu, India; Corresponding author.",
    "Department of Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Quebec, Canada"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "K. Chowdhury"
    },
    {
      "affs": [
        1
      ],
      "name": "S.D.P. Antony"
    },
    {
      "affs": [
        2
      ],
      "name": "A Sanghavi"
    },
    {
      "affs": [
        2
      ],
      "name": "P.K. Elango"
    },
    {
      "affs": [
        0
      ],
      "name": "P. Solete"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bp91ezf60jpj6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jobcr.2026.101565",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2212426826001776",
  "id": "bp91ezf60jpj6",
  "issns": [
    "2212-4268",
    "2212-4276"
  ],
  "landing_url": "https://doi.org/10.1016/j.jobcr.2026.101565",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RK1-715"
    ],
    [
      "openalex",
      "3504|Endodontics and Root Canal Treatments"
    ]
  ],
  "openalex": "W7224547229",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/bp91ezf60jpj6.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:57Z",
      "native_id": "0010fbbbbfd549c6ac367a6f94ed359c",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jobcr.2026.101565"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RK1-715",
      "subfield": "general"
    }
  ],
  "title": "Evaluation of dentinal tubule penetration of a novel nano calcium hydroxide–zinc oxide intracanal medicament: An in vitro pilot study",
  "title_text": "Evaluation of dentinal tubule penetration of a novel nano calcium hydroxide–zinc oxide intracanal medicament: An in vitro pilot study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T14:20:22Z",
  "url": "https://research.draconitic.com/paper/bp91ezf60jpj6",
  "venue": "Journal of Oral Biology and Craniofacial Research",
  "versions": []
}