{
  "abstract": "Background: Evidence on the prognostic associations of programmed death-ligand 1 (PD-L1) and BRCA1-associated protein 1 (BAP1) in pleural mesothelioma (PM) remains inconsistent, and joint data from Latin American cohorts are limited. We evaluated these biomarkers in a Colombian cohort.\n\nMethods: This retrospective single-center cohort included adults with histologically confirmed PM treated at the Instituto Nacional de Cancerología, Bogotá, from January 2011 through December 2023. PD-L1 was quantified using tumor proportion score (TPS), with ≥1% as the primary threshold; BAP1 was classified as retained or lost by nuclear immunoreactivity. Overall survival (OS) was measured from pathologic diagnosis to death. Event-free survival (EFS) was measured from diagnosis to first documented progression or death; patients without an event were censored at last contact. Kaplan–Meier methods and separate multivariable Cox models were used.\n\nResults: Sixty-seven patients were included; 60/67 (89.6%) had locally advanced or metastatic disease. PD-L1 TPS ≥1% was present in 26/67 (38.8%), and BAP1 loss in 47/61 evaluable tumors (77.0%). All 67 patients died. Median OS was 9.20 months (95% CI, 6.11–14.13), and median EFS was 6.51 months (95% CI, 5.49–9.13). PD-L1 TPS ≥1% was not clearly associated with OS (adjusted HR, 1.03; 95% CI, 0.57–1.86) or EFS (adjusted HR, 1.11; 95% CI, 0.62–2.00). BAP1 loss also showed no clear adjusted association with OS (HR, 1.57; 95% CI, 0.78–3.16) or EFS (HR, 1.65; 95% CI, 0.82–3.33).\n\nConclusions: Neither PD-L1 TPS ≥1% nor BAP1 loss showed a clear adjusted association with survival. These jointly measured estimates extend the evidence from an underrepresented Latin American population but require external validation; the exploratory ≥5% and ≥10% analyses were based on only 14 and 7 patients, respectively.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Oncología, Instituto Nacional de Cancerología",
    "Departamento de Cirugía de Tórax, Instituto Nacional de Cancerología y Fundación CTIC",
    "Departamento de Oncología, Clínica Universitaria Colombia, Fundación Universitaria Sanitas",
    "Departamento de Estadística, Instituto Nacional de Cancerología",
    "Departamento de Patología Oncologica, Instituto Nacional de Cancerología",
    "Instituto de Investigación, Universidad FUCS."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ricardo Brugés"
    },
    {
      "affs": [
        1
      ],
      "name": "Carlos Carvajal"
    },
    {
      "affs": [
        2
      ],
      "name": "Angela Luna-Meza"
    },
    {
      "affs": [
        3
      ],
      "name": "Marcela Núñez"
    },
    {
      "affs": [
        4
      ],
      "name": "Alejandra Navarrete"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Rafael Parra-Medina"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bpb62jqqxg0bw.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1920798",
  "fulltext_url": "https://europepmc.org/articles/PMC13713424",
  "id": "bpb62jqqxg0bw",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1920798/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Occupational and environmental lung diseases"
    ]
  ],
  "openalex": "W7221807792",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1920798/pdf",
  "pmcid": "PMC13713424",
  "pmid": "42952559",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/bpb62jqqxg0bw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1920798",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1920798/full"
    },
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42952559",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952559"
    },
    {
      "first_seen": "2026-10-31T12:23:58Z",
      "native_id": "PMC13713424",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fonc.2026.1920798"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2234-943X",
      "subfield": "oncology"
    }
  ],
  "title": "Prognostic associations of PD-L1 expression and BAP1 loss in pleural mesothelioma: a retrospective single-center cohort from Colombia",
  "title_text": "Prognostic associations of PD-L1 expression and BAP1 loss in pleural mesothelioma: a retrospective single-center cohort from Colombia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:06Z",
  "url": "https://research.draconitic.com/paper/bpb62jqqxg0bw",
  "venue": "Frontiers in Oncology",
  "versions": []
}