{
  "abstract": "Lorlatinib is a third-generation anaplastic lymphoma kinase (ALK)/ROS1 tyrosine kinase inhibitor (TKI) that has been shown to have high efficacy in the first line setting for treatment of advanced ALK-rearranged non-small cell lung cancer (NSCLC). However, some adverse events have been described that require proper follow-up and management to obtain the maximum benefit from treatment and minimize risk to the patient. These include dyslipidemia and weight gain, conditions that in Latin America have a high prevalence in the general population, which coupled with limitations in timely access to specialized care, could influence both manifestation and management. The objective of this consensus is to provide recommendations tailored to our real-world setting that will optimize the monitoring and early management of toxicities in patients treated with lorlatinib in Latin America.",
  "abstract_shown": true,
  "affiliations": [
    "Centro de Investigación y Manejo del Cáncer (CIMCA)",
    "Oncology Service, Clinica AMO",
    "Centro de Educación Médica de Investigaciones Clínicas (CEMIC)",
    "Oncosalud-AUNA",
    "Oncology Department, Clínica Alemana",
    "Medical Oncology Department, Oncare",
    "Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo (CTIC)",
    "Clinical Oncology Unit, Centro de excelencia tumores torácicos, Clínica las Américas-AUNA",
    "Medical Oncology Department, Instituto Nacional de Cancerología",
    "Medical Oncology Service, Instituto Alexander Fleming",
    "Oncology Department, Hospital Sírio-Libanês"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Luis Corrales"
    },
    {
      "affs": [
        1
      ],
      "name": "Aknar Freire de Carvalho Calabrich"
    },
    {
      "affs": [
        2
      ],
      "name": "Aldo Agustin Perfetti"
    },
    {
      "affs": [
        3
      ],
      "name": "Luis Alberto Mas López"
    },
    {
      "affs": [
        4
      ],
      "name": "Javier Quilodran Peredo"
    },
    {
      "affs": [
        5
      ],
      "name": "Lizbett Vanessa Garcia Montes"
    },
    {
      "affs": [
        6
      ],
      "name": "Andrés Felipe Cardona Zorrilla"
    },
    {
      "affs": [
        7
      ],
      "name": "Sergio Andrés Mejía Espinosa"
    },
    {
      "affs": [
        8
      ],
      "name": "Maritza Ramos-Pérez"
    },
    {
      "affs": [
        9
      ],
      "name": "Carmen Sofía Pupareli"
    },
    {
      "affs": [
        10
      ],
      "name": "Gulherme Harada"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bpgnqqd0agb57.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1740218",
  "fulltext_url": null,
  "id": "bpgnqqd0agb57",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1740218/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Lung Cancer Treatments and Mutations"
    ]
  ],
  "openalex": "W7223672884",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1740218/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/bpgnqqd0agb57.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "10.3389/fonc.2026.1740218",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1740218/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2234-943X",
      "subfield": "oncology"
    }
  ],
  "title": "Expert recommendations on the management of major and minor toxicities associated with the use of lorlatinib in Latin America",
  "title_text": "Expert recommendations on the management of major and minor toxicities associated with the use of lorlatinib in Latin America",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/bpgnqqd0agb57",
  "venue": "Frontiers in Oncology",
  "versions": []
}