{
  "abstract": "Ultrathin multimode-fibre endoscopes provide minimally invasive access to subcellular structures throughout the depth of the mouse brain. Here we introduce a chronically implantable interface with a diameter of 144 μm, about the thickness of a human hair, that extends this capability to longitudinal imaging, enabling repeated access to the same fine structures over extended periods. The system supports weeks-long tracking of individual dendritic spines, allowing quantitative comparison of their dynamics and survival across dendritic compartments. We further demonstrate longitudinal intracellular calcium imaging during spontaneous and stimulus-evoked activity in the same cells across days, as well as repeated measurements of blood flow in the same vessels across multiple brain regions. This chronic endomicroscopic platform provides stable, minimally invasive optical access for longitudinal subcellular-resolution imaging of brain structure, activity and blood flow across depth.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2611.09481",
  "author_total": 16,
  "authors": [
    {
      "name": "Miroslav Stibůrek"
    },
    {
      "name": "Tomáš Pikálek"
    },
    {
      "name": "Petra Ondráčková"
    },
    {
      "name": "Kristina Herzánová"
    },
    {
      "name": "Adrian Lorenz"
    },
    {
      "name": "André Gomes"
    },
    {
      "name": "Julia Henschke"
    },
    {
      "name": "Endre Levente Marosi"
    },
    {
      "name": "Bhargavi Murthy"
    },
    {
      "name": "Petra Kolbábková"
    },
    {
      "name": "Hongbo Jia"
    },
    {
      "name": "Sanja Bauer Mikulovic"
    },
    {
      "name": "Janelle Pakan"
    },
    {
      "name": "Alessio Attardo"
    },
    {
      "name": "Hana Uhlířová"
    },
    {
      "name": "Tomáš Čižmár"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bpp1qap67mqy1.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2611.09481",
  "fulltext_url": null,
  "id": "bpp1qap67mqy1",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2611.09481",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.optics"
    ],
    [
      "arxiv",
      "q-bio.NC"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://arxiv.org/pdf/2611.09481",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bpp1qap67mqy1.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T06:21:04Z",
      "native_id": "2611.09481",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2611.09481"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "arxiv:q-bio.NC",
      "subfield": "neuroscience"
    },
    {
      "field": "physics",
      "origin": "arxiv:physics.optics",
      "subfield": "optics-photonics"
    }
  ],
  "title": "A hair-thin implant opens the entire depth of the mouse brain to revisiting the same structures at subcellular resolution",
  "title_text": "A hair-thin implant opens the entire depth of the mouse brain to revisiting the same structures at subcellular resolution",
  "type": "preprint",
  "updated_at": "2026-11-10T06:21:10Z",
  "url": "https://research.draconitic.com/paper/bpp1qap67mqy1",
  "venue": "arXiv",
  "versions": []
}