{
  "abstract": "Objectives:: We aimed to assess if the claustrum is involved in seizure networks in humans with epilepsy.\n\nMaterials and Methods:: We identified eight patients submitted for presurgical evaluation with stereoelectroencephalography (SEEG) recordings from the claustrum from 2016-2022. Demographic, paraclinical, and outcome data (Engel Classification) was collected from retrospective chart review. We analyzed the ictal and interictal pattern as well as high frequency oscillations (HFOs) in the claustrum.\n\nResults:: The ictal onset zone was in the temporal lobe in 87% (n=7) of patients and the cingulate cortex in 12% (n=1). A total of 25 seizures were detected and 96% (n=24) involved the claustrum cortex. Of those seizures involving the claustrum, 88% (n=21) were involved before the rest of the electrodes. Two ictal onset patterns were identified: slow potential shift with HFOs were found in 46% (n=11) of seizures and rhythmic spikes <13 hz were found in 54% of seizures (n=13). The ictal pattern in the claustrum was synchronous with the ictal onset zone in 41% (n=10) seizures, however, in four patients with status epilepticus, the claustrum was noted to stop discharging just before ictal onset. The interictal pattern included high-amplitude slow waves with or without HFOs. HFOs were identified in the claustrum in 83% (n=20) of post-ictal periods. All patients had poor outcomes following surgical resection (Engel Class III-IV).\n\nConclusions:: Our study suggests that the claustrum is often involved during seizures arising from the temporal lobe and cingulate cortexes and could play a role in modulation of the epileptogenic network.",
  "abstract_shown": true,
  "affiliations": [
    "Nemours’s Children Hospital, Department of Pediatric, Division of Neurology, Orlando, Florida, United States.",
    "Medical College of Wisconsin, Department of Neurology, Division of Pediatric Neurology, Milwaukee, WI, United States"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rene Andrade Machado"
    },
    {
      "affs": [
        1
      ],
      "name": "Jennifer Meylor"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bpvt4wkpwje64.bib",
  "cited_by": 0,
  "doi": "10.22037/ijcn.v20i4.47731",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723253/",
  "id": "bpvt4wkpwje64",
  "issns": [
    "1735-4668",
    "2008-0700"
  ],
  "landing_url": "https://doi.org/10.22037/ijcn.v20i4.47731",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2738|Epilepsy research and treatment"
    ]
  ],
  "openalex": "W7223008479",
  "pdf_url": "https://journals.sbmu.ac.ir/ijcn/article/download/47731/38181",
  "pmcid": "PMC13723253",
  "pmid": "42967170",
  "published": "2026-09-01",
  "publisher": "Shahid Beheshti University of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/bpvt4wkpwje64.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:53Z",
      "native_id": "PMC13723253",
      "source": "pmc",
      "url": "https://doi.org/10.22037/ijcn.v20i4.47731"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Epilepsy research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Involvement of the Claustrum in Human Epileptic Seizures",
  "title_text": "Involvement of the Claustrum in Human Epileptic Seizures",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:53Z",
  "url": "https://research.draconitic.com/paper/bpvt4wkpwje64",
  "venue": "Iranian Journal of Child Neurology",
  "versions": []
}