{
  "abstract": "The increase in global life expectancy has resulted in a significant rise in the occurrence of Alzheimer's disease (AD), making it a critical public health burden. Therefore, there is an urgent need to create effective methods to prevent or slow down the progression of the disease. In this regard, fifteen previously reported hybrid molecules (7a-c, 10a-j, and 13a,b), combining 4-hydroxycoumarin and pyrazolyl indolin-2-one structures, were resynthesized and tested for their antioxidant and anti-Alzheimer properties. Several of these compounds showed moderate to strong biological activity. Among these, compound 7a demonstrated excellent antioxidant capacity (TAC = 80.65 mg gallic acid/g; IRP = 68.90 µg/mL) and impressive free radical scavenging abilities (DPPH = 5.33 µg/mL; ABTS = 4.59 µg/mL; NO = 6.76 µg/mL), comparable to the standard antioxidant ascorbic acid. Additionally, compound 7a demonstrated the robust inhibition of acetylcholinesterase (AChE) with an IC₅₀ of 6.89 µg/mL, as well as potent inhibition of butyrylcholinesterase (BChE) (IC₅₀ = 5.93 µg/mL). Molecular docking analyses of compound 7a revealed favorable binding interactions and stable conformations within the enzyme's active site, supporting its strong inhibitory effect. Overall, these findings indicate that this group of hybrid molecules offers a promising framework for developing new cholinesterase-targeting treatments for AD.",
  "abstract_shown": true,
  "affiliations": [
    "Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.",
    "Biochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.",
    "Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Kantara branch, Ismailia, Egypt.",
    "Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.",
    "Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.",
    "School of Pharmacy, Fudan University, Shanghai, China.",
    "Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ahmed Sabt",
      "orcid": "0000-0001-6976-0196"
    },
    {
      "affs": [
        1
      ],
      "name": "Wael Mahmoud Aboulthana",
      "orcid": "0000-0002-4848-0731"
    },
    {
      "affs": [
        2
      ],
      "name": "Abdulrahman M Saleh",
      "orcid": "0000-0002-5153-7399"
    },
    {
      "affs": [
        3
      ],
      "name": "Hoda Atef Abdelsattar Ibrahim",
      "orcid": "0000-0001-5399-8861"
    },
    {
      "affs": [
        4
      ],
      "name": "Asmaa Saleh",
      "orcid": "0000-0002-6286-319X"
    },
    {
      "affs": [
        5
      ],
      "name": "Xinsheng Lei",
      "orcid": "0000-0003-1945-4902"
    },
    {
      "affs": [
        6
      ],
      "name": "Aladdin M Srour",
      "orcid": "0000-0002-6692-6952"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bq4yf1xmaxn7q.bib",
  "cited_by": 0,
  "doi": "10.1002/cbdv.71900",
  "fulltext_url": "https://europepmc.org/articles/PMC13724224",
  "id": "bq4yf1xmaxn7q",
  "issns": [
    "1612-1872",
    "1612-1880"
  ],
  "landing_url": "https://europepmc.org/article/MED/42967596",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2736|Cholinesterase and Neurodegenerative Diseases"
    ]
  ],
  "openalex": "W7225040268",
  "pdf_url": "https://europepmc.org/articles/PMC13724224?pdf=render",
  "pmcid": "PMC13724224",
  "pmid": "42967596",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bq4yf1xmaxn7q.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42967596",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42967596"
    },
    {
      "first_seen": "2026-11-04T12:22:43Z",
      "native_id": "PMC13724224",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cbdv.71900"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Cholinesterase and Neurodegenerative Diseases",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Design, Synthesis, and Biological Evaluation of Molecular Hybrids Incorporating Coumarin-Pyrazole-Linked Indolinone Derivatives With Antioxidant and Anti-Alzheimer Properties.",
  "title_text": "Design, Synthesis, and Biological Evaluation of Molecular Hybrids Incorporating Coumarin-Pyrazole-Linked Indolinone Derivatives With Antioxidant and Anti-Alzheimer Properties.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:54Z",
  "url": "https://research.draconitic.com/paper/bq4yf1xmaxn7q",
  "venue": "Chemistry & biodiversity",
  "versions": []
}