{
  "abstract": "Background: Surgery remains standard treatment for localized renal cancer. Whether partial nephrectomy (PN), compared with radical nephrectomy (RN), affects long-term cardiovascular disease-specific mortality (CVD-SM) in stage II disease is uncertain. We assessed this association using competing-risk methods.\n\nMethods: Patients with T2N0M0 renal cancer diagnosed in the SEER database from 2004 to 2022 were included. Missing tumor grade and unspecified T2 subclassification were addressed by multiple imputation. Propensity-score matching was performed within 10 imputed datasets. Cumulative incidence functions were estimated using the Aalen–Johansen method. Fine–Gray models were primary, with cause-specific Cox models as supportive analyses; estimates were pooled across imputations.\n\nResults: The cohort included 14,602 patients (PN, n = 1294; RN, n = 13,308), with a median follow-up of 85 months. After matching, 1290–1292 patients per group were retained. Five-year CVD-SM cumulative incidence was 2.68% after PN and 3.07% after RN; 10-year estimates were 7.18% and 6.63%, respectively. No significant association was observed (Fine–Gray sHR, 1.10; 95% CI, 0.69–1.74; P = 0.690; Cox HR, 1.04; 95% CI, 0.66–1.64; P = 0.867). PN was associated with lower cancer-specific mortality (Fine–Gray sHR, 0.58; 95% CI, 0.42–0.80; P < 0.001).\n\nConclusion: Among patients with stage II renal cancer, surgical approach was not significantly associated with CVD-SM. However, estimate imprecision and unavailable cardiovascular and renal risk factors preclude claims of equivalence or exclusion of clinically meaningful effects. The potential cardiovascular benefit of PN remains uncertain. Its lower cancer-specific mortality should be interpreted cautiously because residual surgical-selection confounding may persist.\n\nSynopsis: Cardiovascular disease-specific mortality represents an important long-term competing risk in patients with stage II renal cancer. No statistically significant association between surgical approach and cardiovascular disease-specific mortality was detected, leaving the cardiovascular survival advantage of partial nephrectomy uncertain.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, Jingzhou First People’s Hospital, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, 434000, China",
    "Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China",
    "The First Clinical Medical College, Ningxia Medical University, Yinchuan, Ningxia, 750004, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yao Hao"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhicheng Dai"
    },
    {
      "affs": [
        1
      ],
      "name": "Feng Li"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Zhenxing Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bqfm1qya59qsy.bib",
  "cited_by": 0,
  "doi": "10.1016/j.tranon.2026.103083",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13717089/",
  "id": "bqfm1qya59qsy",
  "issns": [
    "1936-5233"
  ],
  "landing_url": "https://doi.org/10.1016/j.tranon.2026.103083",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Renal cell carcinoma treatment"
    ]
  ],
  "openalex": "W7223143842",
  "pdf_url": null,
  "pmcid": "PMC13717089",
  "pmid": "42906453",
  "published": "2026-10-21",
  "publisher": "Neoplasia Press",
  "ris": "https://research.draconitic.com/paper/bqfm1qya59qsy.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:21:28Z",
      "native_id": "PMC13717089",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.tranon.2026.103083"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Renal cell carcinoma treatment",
      "subfield": "general"
    }
  ],
  "title": "Cardiovascular disease-specific mortality after partial versus radical nephrectomy for stage II renal cancer: A SEER-based propensity-matched analysis",
  "title_text": "Cardiovascular disease-specific mortality after partial versus radical nephrectomy for stage II renal cancer: A SEER-based propensity-matched analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:28Z",
  "url": "https://research.draconitic.com/paper/bqfm1qya59qsy",
  "venue": "Translational Oncology",
  "versions": []
}