{
  "abstract": "An elderly woman undergoing trastuzumab emtansine (T-DM1) treatment for HER2-positive breast cancer visited our department with purpura, hematuria, proteinuria, and a decreased renal function. A skin biopsy revealed leukocytoclastic vasculitis with immunoglobulin A (IgA) deposition, confirming the diagnosis of IgA vasculitis. Owing to active renal lesions, the patient was treated with prednisolone and cyclophosphamide, which resulted in clinical remission. A renal biopsy performed five months post-treatment revealed persistent mild proliferative glomerulonephritis with fibrotic crescent formation. This case was considered to have T-DM1-associated IgA vasculitis. Although rare, an awareness of the possibility of serious adverse effects associated with drug administration is important.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Nanami Watanabe"
    },
    {
      "name": "Shun Yoshida"
    },
    {
      "name": "Keiichi Osano"
    },
    {
      "name": "Kie Ohkoshi"
    },
    {
      "name": "Toshihisa Ishii"
    },
    {
      "name": "Makiko Konishi"
    },
    {
      "name": "Haruka Nakada"
    },
    {
      "name": "Naoki Ashizawa"
    },
    {
      "name": "Yuko Nakayama"
    },
    {
      "name": "Hiroshi Mitsui"
    },
    {
      "name": "Kazuya Takahashi"
    },
    {
      "name": "Ayumu Nakashima"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bqm98frrkvsgb.bib",
  "cited_by": 2,
  "doi": "10.2169/internalmedicine.6751-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6751-25/_article",
  "id": "bqm98frrkvsgb",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6751-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2727|Renal Diseases and Glomerulopathies"
    ]
  ],
  "openalex": "W7133212635",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6751-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bqm98frrkvsgb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.6751-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6751-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Renal Diseases and Glomerulopathies",
      "subfield": "general"
    }
  ],
  "title": "IgA Vasculitis Developing during Trastuzumab Emtansine Therapy for HER2-positive Breast Cancer",
  "title_text": "IgA Vasculitis Developing during Trastuzumab Emtansine Therapy for HER2-positive Breast Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/bqm98frrkvsgb",
  "venue": "Internal Medicine",
  "versions": []
}