{
  "abstract": "Acute kidney injury (AKI) caused by granulomatous interstitial nephritis (GIN) accompanied by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is extremely rare. A 71-year-old man with severe AKI was diagnosed with CLL/SLL based on bone marrow and lymph node biopsy results. A renal biopsy revealed dense cortical infiltration of CLL/SLL cells and severe interstitial inflammation with granuloma formation, consistent with GIN. Acalabrutinib-Obinutuzumab combination therapy was effective for CLL/SLL, but prednisolone was required to achieve a renal function improvement. A renal biopsy is essential for the diagnosis, and corticosteroids play a key role in managing GIN-associated renal injury, even in the era of targeted therapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Asuka Shibamiya"
    },
    {
      "name": "Chikako Ohwada"
    },
    {
      "name": "Akane Tanaka"
    },
    {
      "name": "Reiko Watanabe"
    },
    {
      "name": "Jun Ito"
    },
    {
      "name": "Yuichiro Hayashi"
    },
    {
      "name": "Takayuki Shiomi"
    },
    {
      "name": "Chiaki Nakaseko"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bqzq9hmfrmhwa.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7400-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7400-26/_article",
  "id": "bqzq9hmfrmhwa",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7400-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2716|Chronic Lymphocytic Leukemia Research"
    ]
  ],
  "openalex": "W7167242627",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7400-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bqzq9hmfrmhwa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7400-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7400-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Chronic Lymphocytic Leukemia Research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Acute Kidney Injury Due to Granulomatous Interstitial Nephritis as the Initial Presentation of CLL/SLL Treated with Acalabrutinib",
  "title_text": "Acute Kidney Injury Due to Granulomatous Interstitial Nephritis as the Initial Presentation of CLL/SLL Treated with Acalabrutinib",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/bqzq9hmfrmhwa",
  "venue": "Internal Medicine",
  "versions": []
}