{
  "abstract": "BackgroundWe examined baseline relative circulating osteocalcin (OCN) in relation to incident dementia in UK Biobank.MethodsThe longitudinal cohort comprised 43,942 participants; models used available complete records. Cox models used baseline OCN standardized per SD and follow-up censored at diagnosis, death, or November 27, 2024. Cognitive, MRI, and baseline molecular analyses were exploratory.ResultsIn the fully adjusted model, OCN was not clearly associated with all-cause dementia (HR 1.052; 95% CI, 0.988–1.120; p = 0.117; N = 40,253; 1,095 events). The vascular dementia estimate was nominally positive (HR 1.159; 95% CI, 1.010–1.328; p = 0.035), but did not survive Holm correction across three secondary outcomes (adjusted p = 0.105) and weakened after excluding baseline stroke. Adding OCN changed the mean fivefold cross-validated C index from 0.84628 to 0.84642 (ΔC = 0.00014). No baseline cognitive association survived Holm correction across four tests. Nominal hippocampal and WMH associations in the larger MRI sample were not evident in matched extensively adjusted samples. Repeated-visit cognitive models did not yield adequately sized multiple classes for interpretable class-membership regressions. Baseline measured-only molecular analyses identified OCN-related correlations, but age- and sex-adjusted BCAA correlations did not survive panel-wise Bonferroni correction.ConclusionBaseline relative OCN did not show a clear fully adjusted all-cause dementia association or useful incremental discrimination. Subtype, cognitive, imaging, and molecular findings remain exploratory. These data do not establish a compensatory mechanism or clinical predictive utility.",
  "abstract_shown": true,
  "affiliations": [
    "Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China",
    "Guilin Medical University, Guilin, China",
    "Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China",
    "Guangxi Clinical Research Center for Reproductive Medicine, Nanning, China",
    "Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China",
    "Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, Guangxi, China",
    "Key Cultivated Laboratory of Cancer Molecular Medicine of Guangxi Health Commission, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China",
    "Guangxi Zhuang Autonomous Region Molecular Medical Engineering Research Center for Cancer, Nanning, Guangxi, China",
    "Department of Epidemiology and Health Statistics, School of Public Health of Guangxi Medical University, Nanning, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xinxiang Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinxiang Su"
    },
    {
      "affs": [
        2
      ],
      "name": "Yan Mao"
    },
    {
      "affs": [
        0
      ],
      "name": "Chao Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongmei Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingjun Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Shengxiang Bi"
    },
    {
      "affs": [
        0
      ],
      "name": "Bo Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Bo Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoqian Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Liang Ren"
    },
    {
      "affs": [
        4
      ],
      "name": "Liang Ren"
    },
    {
      "affs": [
        2
      ],
      "name": "Hongping Yu"
    },
    {
      "affs": [
        5
      ],
      "name": "Hongping Yu"
    },
    {
      "affs": [
        6
      ],
      "name": "Hongping Yu"
    },
    {
      "affs": [
        7
      ],
      "name": "Hongping Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yihua Yang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yihua Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming Liao"
    },
    {
      "affs": [
        3
      ],
      "name": "Ming Liao"
    },
    {
      "affs": [
        8
      ],
      "name": "Ming Liao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/br1b9dgazp7ec.bib",
  "cited_by": 0,
  "doi": "10.3389/fnagi.2026.1974960",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fnagi.2026.1974960/full",
  "id": "br1b9dgazp7ec",
  "issns": [
    "1663-4365"
  ],
  "landing_url": "https://doi.org/10.3389/fnagi.2026.1974960",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC321-571"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7223705790",
  "pdf_url": "https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1974960/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/br1b9dgazp7ec.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:29Z",
      "native_id": "43e8baefb6214b3aa378e837d124295c",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fnagi.2026.1974960"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Circulating osteocalcin and incident dementia in the UK Biobank: a prospective cohort and exploratory multi-omics analysis",
  "title_text": "Circulating osteocalcin and incident dementia in the UK Biobank: a prospective cohort and exploratory multi-omics analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:29Z",
  "url": "https://research.draconitic.com/paper/br1b9dgazp7ec",
  "venue": "Frontiers in Aging Neuroscience",
  "versions": []
}