{
  "abstract": "Aim: To describe age‐specific clinical features and identify predictors of length of hospital stay in children and adolescents with primary Epstein–Barr virus (EBV) infectious mononucleosis (IM).\n\nMethods: This multicentre retrospective cohort study included all children and adolescents aged 0–17 years with a verified primary EBV infection in the Central Denmark Region between March 2020 and March 2025.\n\nResults: Among 1657 serologically verified primary EBV infections, 307 patients (18.5%) required EBV‐related hospitalisation. Hospitalisation incidence increased with age. Although adolescents accounted for most EBV‐related admissions (77.5%), EBV‐infected children below 7 years were hospitalised more often (one in four) than children aged 7 years or older (one in seven). The most common presenting symptoms were tonsillitis (77%), fever (75%) and lymphadenopathy (64%). Hepatic dysfunction was frequent, particularly among adolescents, whereas anaemia and hyperbilirubinemia occurred more often in younger children. Prolonged length‐of‐stay was independently associated with hyperbilirubinemia, elevated C‐reactive protein, organomegaly and secondary bacterial infection.\n\nConclusion: Disease severity in paediatric EBV infection was associated with inflammatory and hepatic complications rather than age. Early identification of these features may support risk stratification and optimise inpatient care.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Paediatric and Adolescent Medicine Aarhus University Hospital Aarhus Denmark",
    "National Heart and Lung Institute Imperial College London London UK",
    "Department of Paediatric and Adolescent Medicine Regional Hospital Randers Randers Denmark",
    "Department of Paediatrics and Adolescent Medicine Gødstrup Hospital Herning Denmark",
    "Department of Clinical Medicine Aarhus University Aarhus Denmark",
    "Department of Clinical Microbiology Aarhus University Hospital Aarhus Denmark"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lasse H. Nyhegn",
      "orcid": "0009-0004-3638-2765"
    },
    {
      "affs": [
        2
      ],
      "name": "Sara Yde Steffensen"
    },
    {
      "affs": [
        2
      ],
      "name": "Sabine Frølich Maarbjerg"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Luise Borch",
      "orcid": "0000-0003-1054-0601"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Marianne Kragh Thomsen",
      "orcid": "0000-0002-3645-6689"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Mette Holm",
      "orcid": "0000-0002-9159-4056"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/br1fvbm398q6c.bib",
  "cited_by": 1,
  "doi": "10.1111/apa.70707",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13747698/",
  "id": "br1fvbm398q6c",
  "issns": [
    "0803-5253",
    "1651-2227"
  ],
  "landing_url": "https://doi.org/10.1111/apa.70707",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|Viral-associated cancers and disorders"
    ]
  ],
  "openalex": "W7203752254",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apa.70707",
  "pmcid": "PMC13747698",
  "pmid": "42619378",
  "published": "2026-08-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/br1fvbm398q6c.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T12:23:42Z",
      "native_id": "PMC13747698",
      "source": "pmc",
      "url": "https://doi.org/10.1111/apa.70707"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Viral-associated cancers and disorders",
      "subfield": "oncology"
    }
  ],
  "title": "Clinical Features and Predictors of Hospital Stay in Paediatric Epstein–Barr Virus Infectious Mononucleosis: A Multicentre Cohort Study",
  "title_text": "Clinical Features and Predictors of Hospital Stay in Paediatric Epstein–Barr Virus Infectious Mononucleosis: A Multicentre Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:24:52Z",
  "url": "https://research.draconitic.com/paper/br1fvbm398q6c",
  "venue": "Acta Paediatrica (Oslo, Norway : 1992)",
  "versions": []
}