{
  "abstract": "Spontaneous calcium (Ca2+) waves play a critical role as internal stimuli in the early developing auditory system before the onset of sensory experiences. However, neither the spatiotemporal control of spontaneous Ca2+ waves nor their impacts on auditory development are well understood. Here we report that a lateral array of inner supporting cells (ISCs) beneath the inner hair cells displays a spontaneous ultra‐long, ultra‐fast, transient Ca2+ flash, termed “Ca2+ lightning”, which triggers a series of simultaneous bursts of Ca2+ waves in the whole cochlea, before the ear canal opening. The Ca2+ lightning margins the cochlear ISCs at different developmental stages that correspondingly exhibit different Ca2+ activities. Triggered by an ATP‐induced high‐level Ca2+ wave, the Ca2+ lightning rapidly propagates laterally into neighboring ISCs through the intricate interplay of the T‐type Ca2+ channel, Anoctamin 1 (Ano1) Ca2+‐activated Cl− channel and Connexin 26 (Cx26). The genetic deletion of Cav3.2, Ano1, or Cx26 abrogates Ca2+ lightning flashes and dysregulates cell development and functions in peripheral cochleae. We propose that cochlear Ca2+ lightning flashes orderly with Ca2+ waves together orchestrate the spatiotemporal maturation processes of the peripheral auditory system before the onset of hearing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology Head & Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China",
    "School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China",
    "Program in Neurosciences and Mental Health SickKids Research Institute Toronto Canada",
    "Department of Physiology University of Toronto Toronto Canada",
    "Shanghai Key Laboratory of Sleep Disordered Breathing Shanghai China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qiang Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Hai‐Peng Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu‐Meng Jiang"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Ke Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming‐Xian Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhen Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Li‐Na Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing‐Wei Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Kai‐Ming Su"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Lu‐Yang Wang"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Hui Wang"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Shan‐Kai Yin"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hao He"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Hai‐Bo Shi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/brkpn6m396cgh.bib",
  "cited_by": 0,
  "doi": "10.1002/exp2.70205",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13402436/",
  "id": "brkpn6m396cgh",
  "issns": [
    "2766-8509",
    "2766-2098"
  ],
  "landing_url": "https://doi.org/10.1002/exp2.70205",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2809|Hearing, Cochlea, Tinnitus, Genetics"
    ]
  ],
  "openalex": "W7171328615",
  "pdf_url": null,
  "pmcid": "PMC13402436",
  "pmid": "42517088",
  "published": "2026-07-26",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/brkpn6m396cgh.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:23:33Z",
      "native_id": "PMC13402436",
      "source": "pmc",
      "url": "https://doi.org/10.1002/exp2.70205"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2809|Hearing, Cochlea, Tinnitus, Genetics",
      "subfield": "neuroscience"
    }
  ],
  "title": "Triggered Calcium Lightning Programs Cochlear Development",
  "title_text": "Triggered Calcium Lightning Programs Cochlear Development",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:13Z",
  "url": "https://research.draconitic.com/paper/brkpn6m396cgh",
  "venue": "Exploration",
  "versions": []
}